Results 91 to 100 of about 55,023 (282)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Variational techniques in non-perturbative QCD
, 2004 We review attempts to apply the variational principle to understand the vacuum of non-abelian gauge theories. In particular, we focus on the method explored by Ian Kogan and collaborators, which imposes exact gauge invariance on the trial Gaussian wave ...
Kovner, Alex, Milhano, J. Guilherme
core +3 more sources
Generalized entropy minimization under full marginal constraints
, 2020 We consider the problem of minimizing a generalized relative entropy, with respect to a reference diffusion law, over the set of path-measures with fully prescribed marginal distributions. When dealing with the actual relative entropy, problems of this kind have appeared in the stochastic mechanics literature, and minimizers go under the name of Nelson
Backhoff-Veraguas, Julio +1 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Constructal Optimization of Rectangular Microchannel Heat Sink with Porous Medium for Entropy Generation Minimization. [PDF]
Entropy (Basel), 2021 Li W, Xie Z, Xi K, Xia S, Ge Y.
europepmc +1 more source
A Codebook Generation Algorithm for Document Image Compression
, 1997 Pattern-matching-based document-compression systems (e.g. for faxing) rely on finding a small set of patterns that can be used to represent all of the ink in the document.
Danskin, John, Young, Neal, Zhang, Qin
core +1 more source
Minimizing the generation of entropy: which sequence of reservoirs to choose?
European Journal of Physics, 2009 This letter deals with irreversible processes described by abrupt changes in temperature or in pressure, in which the system is placed into contact with a finite number N of heat or work reservoirs, respectively. Two previous papers have shown that when N goes to infinity the entropy generation goes to zero, i.e. the process becomes reversible. Here we
Ferreira, J. M., Anacleto, Joaquim
openaire +2 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Entropy generation minimization of higher-order endothermic/exothermic chemical reaction with activation energy on MHD mixed convective flow over a stretching surface. [PDF]
Sci Rep, 2022 Sharma BK +3 more
europepmc +1 more source