Results 51 to 60 of about 7,556 (261)

Application of the EGM Method to a LED-Based Spotlight: A Constrained Pseudo-Optimization Design Process Based on the Analysis of the Local Entropy Generation Maps

Entropy, 2011
In this paper, the entropy generation minimization (EGM) method is applied to an industrial heat transfer problem: the forced convective cooling of a LED-based spotlight.
Enrico Sciubba, Giorgio Giangaspero
doaj   +1 more source

Minimization of entropy generation in heat exchangers

, 2002
131
openaire   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Minimization of entropy generation rate in methanol steam reforming reactor

Case Studies in Thermal Engineering
The methanol steam reforming (MSR) reaction is a prospective method in hydrogen generation because of its operability and high conversion efficiency. Most of the current thermodynamic studies involving MSR use classical thermodynamic methods, while fewer
Rui Kong, Shaojun Xia, Zhihui Xie, Yu Lin   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Optimal Design of Nanoparticle Enhanced Phan-Thien–Tanner Flow of a Viscoelastic Fluid in a Microchannel

Entropy, 2018
The excellent thermal characteristics of nanoparticles have increased their application in the field of heat transfer. In this paper, a thermophysical and geometrical parameter study is performed to minimize the total entropy generation of the ...
Mohammad Yaghoub Abdollahzadeh Jamalabadi
doaj   +1 more source

Thermodynamic Analysis of a High-Temperature Latent Heat Thermal Energy Storage System

Energies, 2020
Thermal energy storage (TES) technologies are becoming vitally important due to intermittency of renewable energy sources in solar applications. Since high energy density is an important parameter in TES systems, latent heat thermal energy storage (LHTES)
David W. MacPhee, Mustafa Erguvan
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Fixed-matrix regenerators optimization with wire mesh screens using entropy generation minimization method

AIP Advances
The thermodynamic efficiency of a wire mesh fixed matrix regenerative heat exchanger mainly depends on the regenerator’s heating performance and losses.
Mohammad Saraireh
doaj   +1 more source