Results 51 to 60 of about 7,508 (293)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

SELECTING OPTIMAL DISTILLATION CONFIGURATIONS THAT MINIMIZE THE OVERALL RATE OF ENTROPY GENERATION

, 2023
Engineers have long sought to improve the thermodynamic efficiency of heat transfer equipment. One metric that quantifies thermodynamic inefficiency is the rate of entropy generation.
Olson, Zachary A.
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Entropy Generation Minimization for the Design of Plate Heat Exchangers

TECNICA ITALIANA-Italian Journal of Engineering Science, 2019
Plate heat exchangers are widespread in several fields due to their capability to transfer noticeable thermal powers despite the reduced encumbrance. The main feature concerns the presence of parallel plates where the fluids circulate in alternate manner in counter-current configuration.
Bruno Roberto, Bevilacqua P., Ferraro V., Arcuri N.   +3 more
openaire   +3 more sources

Semi-analytical Evaluation of Entropy Generation in 1-D Heat Conduction with Variable Thermal Conductivity [PDF]

, 2019
In the present study, steady state heat transfer in a slab is analysed by applying the principle of variation calculus to the entropy generation minimization.
Noble, Sharmaa, Praveen Reddya, A, Narayan Rao, N, Anupkumar, T, Srinivasa Rao, B   +4 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Exergy Analysis of a Domestic Refrigerator

Journal of Engineering, 2018
An energy and exergy thermodynamic analysis using EES program was done for a domestic refrigerator working with R-134a using vapor compression refrigeration cycle. The analysis deals with the system component, i.e.
Loauy Abd Al-Azez Mahdi, Wahid S. Mohammad, Samir Akram Mahmood   +2 more
doaj   +1 more source

Entropy Generation Minimization in Dimethyl Ether Synthesis: A Case Study

, 2018
Entropy generation minimization is a method that helps improve the efficiency of real processes and devices. In this article, we study the entropy production (due to chemical reactions, heat exchange and friction) in a conventional reactor that ...
Adrián César Razzitte, Diego Kingston
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source