Results 91 to 100 of about 268,561 (292)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A Statistical Mechanical Load Balancer for the Web
, 2005 The maximum entropy principle from statistical mechanics states that a closed system attains an equilibrium distribution that maximizes its entropy. We first show that for graphs with fixed number of edges one can define a stochastic edge dynamic that ...
C. Avin +8 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Second Law Analysis of Laminar Flow In A Channel Filled With Saturated Porous Media
Entropy, 2005 The entropy generation rate in a laminar flow through a channel filled with saturated porous media is investigated. The upper surface of the channel is adiabatic and the lower wall is assumed to have a constant heat flux.
E. Osalusi, O. D. Makinde
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Simulation of Entropy Generation under Stall Conditions in a Centrifugal Fan
Entropy, 2014 Rotating stalls are generally the first instability met in turbomachinery, before surges. This 3D phenomenon is characterized by one or more stalled flow cells which rotate at a fraction of the impeller speed. The goal of the present work is to shed some
Lei Zhang +3 more
doaj +1 more source
Phase-space characterization of complexity in quantum many-body dynamics
, 2010 We propose a phase-space Wigner harmonics entropy measure for many-body quantum dynamical complexity. This measure, which reduces to the well known measure of complexity in classical systems and which is valid for both pure and mixed states in single ...
A. Auerbach +8 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Polynomial complexity of polar codes for non-binary alphabets, key agreement and Slepian-Wolf coding
, 2014 We consider polar codes for memoryless sources with side information and show that the blocklength, construction, encoding and decoding complexities are bounded by a polynomial of the reciprocal of the gap between the compression rate and the conditional
Abbe, Emmanuel, Liu, Jingbo
core +1 more source