Results 61 to 70 of about 153,546 (278)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Topological Entropy of Surface Braids and Maximally Efficient Mixing

SIAM Journal on Applied Dynamical Systems, 2022
The deep connections between braids and dynamics by way of the Nielsen-Thurston classification theorem have led to a wide range of practical applications. Braids have been used to detect coherent structures and mixing regions in oceanic flows, drive the design of industrial mixing machines, contextualize the evolution of taffy pullers, and characterize
Smith, Spencer A., Dunn, Sierra
openaire   +2 more sources

Turbulence in Galaxy Cluster Cores: a Key to Cluster Bimodality?

, 2010
We study the effects of externally imposed turbulence on the thermal properties of galaxy cluster cores, using three-dimensional numerical simulations including magnetic fields, anisotropic thermal conduction, and radiative cooling. The imposed "stirring"
Binney, Bogdanović, Burns, Cavagnolo, Conroy, Donahue, Guo, Haarsma, Kim, Lau, Lemaster, Narayan, Parrish, Parrish, Parrish, Pratt, Quataert, Ruszkowski, Sharma, Stone, Tozzi, Voit, Woosley, ZuHone   +23 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

KeV Warm Dark Matter and Composite Neutrinos

, 2012
Elementary keV sterile Dirac neutrinos can be a natural ingredient of the composite neutrino scenario. For a certain class of composite neutrino theories, these sterile neutrinos naturally have the appropriate mixing angles to be resonantly produced warm
A Anisimov, A Boyarsky, A Boyarsky, A Boyarsky, A Boyarsky, A Boyarsky, A Boyarsky, A Dolgov, A Kusenko, A Kusenko, A Kusenko, A Merle, A Rajaraman, C-Q Geng, CR Watson, D Aristizabal Sierra, D Boyanovsky, Dean J. Robinson, E Farhi, E Komatsu, F Bezrukov, GB Gelmini, H Vega de, H Vega de, J Beringer, J Wu, J Zavala, K Abazajian, K Petraki, KA Olive, KL McDonald, M Duerr, M Laine, M Loewenstein, M Loewenstein, M Shaposhnikov, N Arkani-Hamed, P Bode, PJ Fox, PL Biermann, R Hundi, S Das, S Dodelson, T Araki, T Asaka, T Csorgo, T DeGrand, T Okui, U Seljak, W Liao, X-D Shi, Y Grossman, Y Grossman, Yuhsin Tsai   +53 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A Novel Mixing Index Based on Directional Branch Length Similarity Entropy on Delaunay Networks

IEEE Access
Quantitative evaluation of particle mixing is a fundamental task in science and industry, but existing indices often fail under spatial heterogeneity and irregular boundaries.
Sang-Hee Lee, Cheol-Min Park
doaj   +1 more source

MoNbTaV Medium-Entropy Alloy

Entropy, 2016
Guided by CALPHAD (Calculation of Phase Diagrams) modeling, the refractory medium-entropy alloy MoNbTaV was synthesized by vacuum arc melting under a high-purity argon atmosphere. A body-centered cubic solid solution phase was experimentally confirmed in
Hongwei Yao, Jun-Wei Qiao, Michael C. Gao, Jeffrey A. Hawk, Sheng-Guo Ma, Hefeng Zhou   +5 more
doaj   +1 more source

Turbulent Mixing in Clusters of Galaxies

, 2003
We present a spherically-symmetric, steady-state model of galaxy clusters in which radiative cooling from the hot gas is balanced by heat transport through turbulent mixing. We assume that the gas is in hydrostatic equilibrium, and describe the turbulent
Brighenti F., Churazov E., Deiss B. M., Ramesh Narayan, Valageas P., White D. A., Woong-Tae Kim   +6 more
core   +1 more source