Results 91 to 100 of about 442,315 (312)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Minimizing Entropy and Complexity in Creative Production from Emergent Pragmatics to Action Semantics

Entropy
New insights into intractable industrial challenges can be revealed by framing them in terms of natural science. One intractable industrial challenge is that creative production can be much more financially expensive and time consuming than standardized ...
Stephen Fox
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Entropy Production in Relativistic Binary Mixtures

, 2011
In this paper we calculate the entropy production of a relativistic binary mixture of inert dilute gases using kinetic theory. For this purpose we use the covariant form of Boltzmann's equation which, when suitably transformed, yields a formal expression
Garcia-Colin, L. S., Garcia-Perciante, A. L., Moratto, Valdemar   +2 more
core   +1 more source

A model of evapotranspiration based on the theory of maximum entropy production [PDF]

Water Resources Research, 2011
Building on a proof‐of‐concept study of energy balance over dry soil, a model of evapotranspiration is proposed based on the theory of maximum entropy production (MEP). The MEP formalism leads to an analytical solution of evaporation rate (latent heat flux), together with sensible and ground heat fluxes, as a function of surface soil temperature ...
Jingfeng Wang, R. L. Bras
openaire   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Entropy Production and Thermal Conductivity of A Dilute Gas

, 2011
It is known that the thermal conductivity of a dilute gas can be derived by using kinetic theory. We present here a new derivation by starting with two known entropy production principles: the steepest entropy ascent (SEA) principle and the maximum ...
Zhang, Yong-Jun
core   +1 more source

Celebrating Cercignani's conjecture for the Boltzmann equation

, 2010
Cercignani's conjecture assumes a linear inequality between the entropy and entropy production functionals for Boltzmann's nonlinear integral operator in rarefied gas dynamics.
A. A. Arsen'ev, A. V. Bobylev, A. V. Bobylev, A. V. Bobylev, A. V. Bobylev, A. V. Bobylev, B. Wennberg, B. Wennberg, C. Baranger, C. Cercignani, C. Cercignani, C. Mouhot, C. Mouhot, C. Mouhot, C. Mouhot, C. Mouhot, C. Mouhot, C. S. Wang Chang, C. Villani, C. Villani, C. Villani, C. Villani, C. Villani, C. Villani, Clément Mouhot, Cédric Villani, D. Bakry, D. Hilbert, D. K. Maslen, E. A. Carlen, E. A. Carlen, E. A. Carlen, E. A. Carlen, E. A. Carlen, E. A. Carlen, E. A. Carlen, E. A. Carlen, E. A. Carlen, E. A. Carlen, E. Janvresse, F. Golse, F. Hérau, G. Toscani, G. Toscani, G. Toscani, H. Grad, I. Csiszar, I. M. Gamba, J. C. Maxwell, L. Arkeryd, L. Boltzmann, L. Desvillettes, L. Desvillettes, L. Desvillettes, L. Desvillettes, L. Desvillettes, L. Desvillettes, L. Desvillettes, L. Desvillettes, L. Gross, L. Landau, Laurent Desvillettes, M. Aizenman, M. Kac, M. Klaus, M. P. Gualdani, P. Degond, P. Degond, P. Diaconis, P. T. Gressman, P.-L. Lions, R. Alexandre, R. Alexandre, R. Alexandre, R. Alonso, R. E. Caflisch, S. Kullback, S. Mischler, S. Mischler, T. Carleman, Y. Guo, Y. P. Pao   +81 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source