Results 91 to 100 of about 2,530,373 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ohio guidelines for quality entry year programs

, 2002
Cover title.; "Based on the work of Ohio's Entry Year Advisory Council. Performed under The Title II Teacher Quality Initiative."; "May 2002.

core  

Paramyxovirus Entry

, 2013
The family Paramyxoviridae consists of a group of large, enveloped, negative-sense, single-stranded RNA viruses and contains many important human and animal pathogens. Molecular and biochemical characterization over the past decade has revealed an extraordinary breadth of biological diversity among this family of viruses.
Katharine N, Bossart, Deborah L, Fusco, Christopher C, Broder   +2 more
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Excessive entry in a bilateral oligopoly [PDF]

In a bilateral oligopoly, Ghosh and Morita (‘Social desirability of free entry: a bilateral oligopoly analysis, 2007, IJIO) show that entry is always socially insufficient if the upstream agents have sufficiently strong bargaining power.
Arijit Mukherjee
core   +2 more sources

Structured peer engagement for early-stage medical students provides a safe space and creates a sense of community, combatting imposter syndrome and improving wellbeing

BMC Medical Education
Background Medical education is consistently associated with high rates of psychological distress, with global studies showing depression affects over a quarter of medical students and nearly half experience anxiety or burnout.
Mark Polemidiotis, Nadim Sayani, Sinead O’Kelly, Seamus Sreenan, Marian Brennan   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The effects of entry on incumbent innovation and productivity [PDF]

, 2009
How does firm entry affect innovation incentives in incumbent firms? Microdata suggest that there is heterogeneity across industries. Specifically, incumbent productivity growth and patenting is positively correlated with lagged greenfield foreign firm ...
Rachel, Griffith, Richard Blundell, Susanne, Prantl, Blundell, Richard, Howitt, Peter, Rachel Griffith, Aghion, Philippe, Richard, Blundell, Blundell, R., Griffith, R., Peter Howitt, Philippe Aghion, Peter, Howitt, Prantl, S., Susanne Prantl, Prantl, Susanne, Griffith, Rachel; id_orcid, Aghion, P., Howitt, P.   +18 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FIT45

Molecular Therapy: Nucleic Acids, 2017
HIV entry into target cells is a highly sequential and time-sensitive process. In recent years, potent HIV Env-targeting antibodies, such as VRC01, have been identified.
Alexander Falkenhagen, Sadhna Joshi
doaj   +1 more source