Results 141 to 150 of about 103,974 (267)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Counting on matrices [PDF]

Enumerative Combinatorics and Applications, 2021
Sajal Mukherjee, Sanjay Mukherjee
doaj  

The establishment of Health and Demographic Surveillance system (HDSS) in Bauchi State North East Nigeria; baseline findings, challenges and lessons learned. [PDF]

Glob Health Action
Muhammad Bose I, Dabo MM, Abdullahi Kobi M, Musa A, Ibrahim Amaya S, Dahiru A, Yaya J, Dattijo LM, Muir JA, Bashir MF.   +9 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

CellSearch-based isolation of circulating tumor cells from ascitic fluid enables molecular characterization of ovarian cancer. [PDF]

J Liq Biopsy
Gorini F, Maloberti T, Coschina E, Mezzapesa F, Petrovic B, Gallerani G, Ferracin M, Scarpelli E, De Leo A, Kurelac I, De Iaco P, Angelini S, Perrone AM, de Biase D, Ravegnini G.   +14 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Enumeration of Microscopic Ovarian Structures in Rodents: Best Practices and Toxicological Significance. [PDF]

Birth Defects Res
Coder PS, Vidal JD, Picut CA, Dray BK, Baily J, de Rijk E, Zimmerman B.   +6 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Improvements in chemical reaction pathway exploration algorithms and dataset generation. [PDF]

Sci Data
Dong Z, Zhang H, Li B, Mi S, Yin J, Wang J, Ma J, Zhu T.   +7 more
europepmc   +1 more source