Results 161 to 170 of about 103,974 (267)

Serology Confirms Near-Absence of Malaria Transmission in Timor-Leste. [PDF]

Am J Trop Med Hyg
Amaral EF, Byrne I, Brazal Monzo H, Sarmento R, Do Rosario De Fatima Mota M, Rangel G, Tanesi M, Salles de Sousa A, Martins N, Oakley T, Alves L, Yan J, Arkell P, Francis JR, Drakeley C.   +14 more
europepmc   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Inactivation kinetics of <i>Cronobacter sakazakii</i> and <i>Salmonella enterica</i> in reconstituted powdered infant formula and survival during subsequent storage. [PDF]

Front Microbiol
Kaur G, Fay ML, Raju RM, Pendyala BS, Alva SS, Newkirk R, Stewart DS, Fleischman G, Zhang W, Salazar JK.   +9 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Right to Be Counted: Unmasking First Nations and Métis Population Undercounts in Winnipeg, Manitoba. [PDF]

Int J Environ Res Public Health
Avery L, Snyder M, Cyr M, Herrera D, Star L, Sinclair S, Smylie J, Rotondi M.   +7 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Survivors' Responses to an Online Intervention to Promote Discussions of Cancer Genetic Risk with Blood Relatives.

Public Health Genomics
Zhao J, McBride CM, Shepperd JA, An W, Escoffery C, Ward K, Pentz RD, Guan Y.   +7 more
europepmc   +1 more source

A novel imaging-based approach for large extracellular vesicle detection and prognostic stratification in metastatic breast cancer. [PDF]

J Liq Biopsy
Papp E, Liégeois V, Vandesompele J, Vermeulen P, Mestdagh P, Kockx M.   +5 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source