Results 41 to 50 of about 54,439 (174)

Supervised Exercise Intervention Restores Physical Activity and MultiOMIC‐Derived Frailty Biomarkers in Older Adults

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions.
Diego Marcos‐Perez, Sara Cruces‐Salguero, Morelva Saeteros, Rafael Garcia Molina, Ruben Alcantud‐Córcoles, Cristina Alonso‐Bouzon, Itziar Vergara, Sergio J. Sanabria, Leocadio Rodriguez‐Mañas, Pedro Abizanda, Ander Matheu   +10 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, Volume 600, Issue 12, Page 1782-1800, June 2026.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Boletín Envejecimiento y Desarrollo - No.20

, 2023
El presente número del Boletín de Envejecimiento y Derechos de las Personas Mayores se centra en un evento de enorme relevancia para la región en lo que respecta a la agenda de derechos humanos de las personas mayores, como fue la QuintaConferencia ...

core  

Envejecimiento activo en Latinoamérica: Revisión narrativa de la literatura

Horizonte Sanitario
Objetivo: Presentar una revisión narrativa de la literatura sobre el envejecimiento activo en Latinoamérica. Material y métodos: La búsqueda de artículos se efectuó en las bases de datos EBSCO Host, Web of Science, SciELO, Redalyc, Dialnet plus, JSTOR,
María Alejandra Favela Ocaño, María del Carmen Castro Vásquez   +1 more
doaj   +1 more source

Digital speech‐based markers to advance prognosis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Validated prognostic tools are essential to advance drug development and clinical care in Alzheimer's disease, particularly as the field shifts toward the prevention of cognitive decline. While progress has been made in developing blood‐based biomarkers for the early detection of amyloid pathology, amyloid positivity alone does not reliably ...
Melissa Lee, Stephan Meylan, Eli Shobin, the SpeechDx Consortium, Laura Nisenbaum, Aishwarya Sukumar, Lampros Kourtis   +6 more
wiley   +1 more source

Validity of the two different scoring methods of the Clinical Dementia Rating scale in staging and detection of cognitive impairment in the Peruvian population

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION In Peru, the Global Deterioration Scale is the only available tool for assessing dementia severity. The Spanish translation and cultural adaptation of the Clinical Dementia Rating (CDR) is used locally but requires formal psychometric validation in the Peruvian sociocultural context.
Junior Senador, Rosa Montesinos, Belén Custodio, Jose Huilca, Katherine Agüero, Graciet Verastegui, Pamela Bartolo, Milagros Nuñez‐Huanca, María Fe Albujar Pereira, Nilton Custodio   +9 more
wiley   +1 more source

Boletín Envejecimiento y Desarrollo No. 1 [PDF]

, 2005
Estrategia Regional: Los avances de Centroamérica y el Caribe Hispano. José Luis Machinea: Seguridad social: el próximo desafío. Martha Pelaez: “La vejez debe mirarse con un enfoque familiar”.

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Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins

EMBO Reports
Telomeres are essential for chromosome protection and genomic stability, and telomerase function is critical for organ homeostasis. Zebrafish is a useful vertebrate model for understanding cellular and molecular mechanisms of regeneration.
Elena Martínez-Balsalobre, Monique Anchelin, David Hernández-Silva, Maria C Mione, Victoriano Mulero, Francisca Alcaraz-Pérez, Jesús García-Castillo, María L Cayuela   +7 more
doaj   +1 more source

Physical Fitness and Cognitive Performance in Preschool Children: Cross‐Sectional and Longitudinal Associations From the ELFIT Trial

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 6, June 2026.
ABSTRACT Growing evidence shows that physical fitness and cognitive function might be interrelated, but evidence is mostly cross‐sectional and research in preschool children remains scarce. We aimed to analyze both cross‐sectional and longitudinal associations between fitness indicators and cognitive outcomes in preschoolers. In this secondary analysis
Carlos Martin‐Martinez, Pedro L. Valenzuela, Asier Mañas, Oscar Martinez‐de‐Quel   +3 more
wiley   +1 more source

La medición del envejecimiento (2ª edición) [PDF]

, 2014
La medición del envejecimiento tiene un uso potencialmente extraordinario en el ámbito económico y sanitario. En este informe se recogen las medidas tradicionales y otras formas novedosas de medir basadas en la esperanza de vida y la discapacidad, y ...
Ramiro Fariñas, Diego, Abellán García, Antonio, Pujol Rodríguez, Rogelio   +2 more
core   +1 more source