Results 41 to 50 of about 8,004 (178)

Decoding the Heterogeneity of Diffuse Large B‐Cell Lymphomas: A Comprehensive Genetic, Transcriptomic, and Phenotypic Profiling of B‐Cell Lymphoma Cell Lines

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most prevalent form of non‐Hodgkin lymphoma, exhibiting significant molecular and clinical heterogeneity. Advances in classification integrating phenotypic, genetic, and transcriptomic features have improved diagnosis and prognosis.
Marina Pérez‐Aguilera, Lucía Pedrosa, Sagrario Gómez, Sara Salazar‐Ortego, Ismael Fernández‐Miranda, Rafael Muñoz‐Viana, Paloma Martín‐Acosta, Beatriz L. Martín‐Lunas, Rebeca Jimeno, Natalia Yanguas‐Casás, Beatriz Horcajo, Giovana Roncador, José A. Martínez‐Climent, Ana Ortega‐Molina, Margarita Sánchez‐Beato   +14 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, Volume 600, Issue 12, Page 1782-1800, June 2026.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Digital speech‐based markers to advance prognosis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Validated prognostic tools are essential to advance drug development and clinical care in Alzheimer's disease, particularly as the field shifts toward the prevention of cognitive decline. While progress has been made in developing blood‐based biomarkers for the early detection of amyloid pathology, amyloid positivity alone does not reliably ...
Melissa Lee, Stephan Meylan, Eli Shobin, the SpeechDx Consortium, Laura Nisenbaum, Aishwarya Sukumar, Lampros Kourtis   +6 more
wiley   +1 more source

Validity of the two different scoring methods of the Clinical Dementia Rating scale in staging and detection of cognitive impairment in the Peruvian population

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION In Peru, the Global Deterioration Scale is the only available tool for assessing dementia severity. The Spanish translation and cultural adaptation of the Clinical Dementia Rating (CDR) is used locally but requires formal psychometric validation in the Peruvian sociocultural context.
Junior Senador, Rosa Montesinos, Belén Custodio, Jose Huilca, Katherine Agüero, Graciet Verastegui, Pamela Bartolo, Milagros Nuñez‐Huanca, María Fe Albujar Pereira, Nilton Custodio   +9 more
wiley   +1 more source

Physical Fitness and Cognitive Performance in Preschool Children: Cross‐Sectional and Longitudinal Associations From the ELFIT Trial

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 6, June 2026.
ABSTRACT Growing evidence shows that physical fitness and cognitive function might be interrelated, but evidence is mostly cross‐sectional and research in preschool children remains scarce. We aimed to analyze both cross‐sectional and longitudinal associations between fitness indicators and cognitive outcomes in preschoolers. In this secondary analysis
Carlos Martin‐Martinez, Pedro L. Valenzuela, Asier Mañas, Oscar Martinez‐de‐Quel   +3 more
wiley   +1 more source

Envejecimiento activo en Latinoamérica: Revisión narrativa de la literatura

Horizonte Sanitario
Objetivo: Presentar una revisión narrativa de la literatura sobre el envejecimiento activo en Latinoamérica. Material y métodos: La búsqueda de artículos se efectuó en las bases de datos EBSCO Host, Web of Science, SciELO, Redalyc, Dialnet plus, JSTOR,
María Alejandra Favela Ocaño, María del Carmen Castro Vásquez   +1 more
doaj   +1 more source

Biología del envejecimiento [PDF]

Revista médica de Chile, 2009
Estudios de la biologia del envejecimiento han dado un vuelco significativo en el ultimo decenio. Aparte de una mayor comprension de los aspectos fisiologicos, un avance importante ha sido la identificacion de al menos una centena de genes que controlan el proceso.
Pérez, Viviana, Sierra, Felipe
openaire   +2 more sources

Speech‐based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Early detection of Alzheimer's disease (AD) is critical for timely intervention as disease‐modifying treatments emerge. Speech‐based digital biomarkers offer scalable options for remotely capturing speech‐derived functional changes associated with early cognitive decline, but validation across real‐world populations remains ...
Alexandra König, Johannes Tröger, Elisa Mallick, Nicklas Linz, Craig Ritchie, Sarah Gregory, Matthew Hunter, Kay Johnson, Gonzalo Sánchez Benavides, Oriol Grau‐Rivera, Andreea Radoi, Claudia Porta‐Mas, Stefanie Köhler, Stefan Teipel, Oskar Hansson, Pontus Tideman, Anika Wuestefeld, Sebastian Palmqvist   +17 more
wiley   +1 more source

Envejecimiento normal

Revista Estomatología, 1993
El envejecimiento normal o fisiológico está más cerca de la salud que de la enfermedad; el envejecimiento como proceso natural no es deteriorante y ésta es una idea que se debe resaltar. El envejecimiento biológico comprende los cambios orgánicos estructurales y.funcionales en los seres vivos y en el ser humano a nivel macroscópico y microscópico.
openaire   +1 more source

Comparative Analysis of Dietary Patterns in Children With Phenylketonuria Phenotypes and Controls: Implications for Nutritional Status

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Individuals with phenylketonuria (PKU), caused by different variants of the phenylalanine hydroxylase gene, need to restrict their intake of phenylalanine. This study evaluated dietary patterns and physical activity levels in children with different PKU phenotypes compared to healthy controls. Eighty‐two children were recruited (22 classic PKU
Dolores Garcia‐Arenas, Aida Ormazabal, Paula Isern, Blanca Barrau‐Martinez, Arnau Gonzalez‐Rodriguez, Alba Tor‐Roca, Rafael Llorach, Jaume Campistol‐Plana, Mireia Urpi‐Sarda, Consortium PKU.cat.   +9 more
wiley   +1 more source