Results 61 to 70 of about 3,580,446 (245)
Addressing Pollution‐Related Global Environmental Health Burdens
GeoHealth, 2018 New analyses are revealing the scale of pollution on global health, with a disproportionate share of the impact borne by lower‐income nations, minority and marginalized individuals.
Gabriel M. Filippelli, Mark P. Taylor
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Mенаџмент у хотелијерству и туризму, 2013 Degradation of enviroment represents a global problem, and its moving with an unpresidented pace. Due to human activities, during second half of the twentieth century, Earths ecosystem suffered transformation faster than any period in the worlds history.
Snežana Knežević +2 more
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ECOLABELS FOR LEATHER AND LEATHER PRODUCTS [PDF]
Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2017 Nowadays, there is an increasing demand for consumer goods ecolabelling, coming from consumers concern for adverse environmental impacts of industrial pollution and manufacturers need to protect their existing markets and to expand into new ones ...
BUCIŞCANU Ingrid - Ioana
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Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
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FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
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Journal of Pharmaceutical Policy and Practice, 2019 Background Expired or unused medicines are potentially toxic substances that should be managed effectively to avoid accumulation of potentially toxic pharmaceuticals in the environment. In Nigeria, there is currently limited literature on the methods and
Iweh Michael +4 more
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, 2012 AbstractWork environment research is a vibrant area not only within environmental psychology, but also in a broad range of building sciences concerned with making buildings work for their inhabitants. Understanding how work environments affect comfort, satisfaction, performance, and health comes through the study of such processes as privacy, attention,
openaire +2 more sources