Results 61 to 70 of about 7,653,177 (313)

Associations of heart rates and respiratory rates with lifestyle and environmental factors in toddlers: a nationwide cohort study

open access: yesBMC Pediatrics
Background Heart rate (HR) and respiratory rate (RR) are key vital signs, yet few large studies have reported their normal values in toddlers. We thus assessed HR and RR in two-year-old Japanese children.
Keita Kanamori   +3 more
doaj   +1 more source

Environmental enrichment, age and PPARα interact to regulate proliferation in neurogenic niches

open access: yesFrontiers in Neuroscience, 2016
Peroxisome proliferator-activated receptor alpha (PPARα) ligands have been shown to modulate recovery after brain insults such as ischemia and irradiation by enhancing neurogenesis. In the present study, we investigated the effect of the genetic deletion
Margarita ePerez-Martin   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Desert dermatoses (Thar desert, India)

open access: yesIndian Journal of Dermatology, 2017
Desert dermatology describes the cutaneous changes and the diseases affecting those living in the desert. Diurnal variation in temperature is high and is characteristic of the deserts. The lack of water affects daily activities and impacts dermatological
Manas Chatterjee
doaj   +1 more source

VIRTUAL LEARNING ENVIRONMENTS: FORMAL ENVIRONMENTS VS INFORMAL ENVIRONMENTS

open access: yesINTED Proceedings, 2019
Society is constantly evolving and has so many repercussions on a social level as well as within personal and professional life. Information Technology (IT) has an increasing impact, bringing new challenges and paradigms to Education, by combining formal and informal environments in the communication that takes place between teachers and students, as ...
Gonçalves, Maria José Angélico   +3 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The state of New Zealand's environment: commentary by the Parliamentary Commissioner for the Environment on Environment Aotearoa 2015 [PDF]

open access: yes, 2016
This is a commentary by the Commissioner on Environment Aotearoa 2015 – the state of the environment report published last year by the Ministry for the Environment and Statistics New Zealand.
Parliamentary Commissioner for the Environment (New Zealand)
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Sustentabilidad ambiental y contradicciones sociales Environmental sustainability and social contradictions

open access: yesAmbiente & Sociedade, 1999
Neste artigo analisamos as definições e medições de sustentabilidade. Mostramos que enquanto as definições incluem um elemento inter-geração e um outro de equidade intra-geração, a maioria das medições somente recuperam o primeiro elemento. Explicamos as
Guillermo Foladori
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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