Results 101 to 110 of about 3,674,725 (306)

The public sector in the Caribbean : issues and reform options [PDF]

The public sector's performance in the Caribbean varies, in reducing poverty and in creating an enabling environment for growth. Barbados and the Bahamas have been the high performers, Guyana and the Dominican Republic have been sluggish, and the other ...
Swaroop, Vinaya
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Estimating the societal costs and benefits of de-implementation of low-value care: developing a modelling approach through case assessment

BMC Health Services Research
Background Previous estimates of potential costs savings from de-implementation of low-value care have been calculated with simple modelling approaches, focused on direct medical costs and did not take substitution into account.
Adriënne Henderika Rotteveel, Petrus Paulus Franciscus Klein, Marlous Joyann Rodriguez, Marleen Elizabeth Jansen, Meike M. Klaassen   +4 more
doaj   +1 more source

The Economic Value of Improved Wastewater Irrigation: A Contingent Valuation Study in Addis Ababa, Ethiopia [PDF]

In developing countries the use of wastewater for irrigation can cause considerable harm to public health and the environment. This paper uses contingent valuation to estimate the economic value of safe use of wastewater for crop production on farms ...
Boelee, Eline, Dabbert, Stephan, Fror, Oliver, Weldesilassie, Alebel B.   +3 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Editorial: Antimicrobial resistance: agriculture, environment and public health within One Health framework. [PDF]

Front Microbiol, 2023
Li T, Hao H, Hou X, Xia J.
europepmc   +1 more source

Technologies for the marketplace from the Centers for Disease Control [PDF]

The Centers for Disease Control, a Public Health Service agency, is responsible for the prevention and control of disease and injury. Programs range from surveillance and prevention of chronic and infectious diseases to occupational health and injury ...
Greene, R. Eric, Malvitz, Dolores M., Reid-Sanden, Frances L.   +2 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Evaluating the Dutch Action Plan on Physical Activity From a Systems’ Perspective

Baltic Journal of Sport and Health Sciences
Purpose: The Dutch Ministry of Health, Welfare and Sport wants to make it easier for people to be active every day. This requires changes to the living environment, like improving cycling paths, and cooperation across domains such as healthcare ...
Wanda Wendel-Vos, Eline Vos, Suzanne van Mourik-Boelema, Lidwien Lemmens, Tess van de Valk, Saskia van den Berg   +5 more
doaj   +1 more source