Results 71 to 80 of about 6,530,247 (308)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Knowledge data discovery and data mining in a design environment [PDF]
, 2000 Designers, in the process of satisfying design requirements, generally encounter difficulties in, firstly, understanding the problem and secondly, finding a solution [Cross 1998].
Duffy, Alex, Haffey, Mark
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Real time resource scheduling within a distributed collaborative design environment [PDF]
, 2007 Operational design co-ordination is provided by a Virtual Integration Platform (VIP) that is capable of scheduling and allocating design activities to organisationally and geographically distributed designers.
Coates, G. +2 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Numerical Analysis and Geometry Optimisation of Vertical Vane of Room Air-conditioner
MATEC Web of Conferences, 2018 Vertical vanes of room air-conditioners are used to control and direct cold air. This paper aims to study vertical vane as one of the parameters that affect the efficiency of dissipating cold air to a given space.
Al-Obaidi Abdulkareem Sh. Mahdi +3 more
doaj +1 more source
Design response to rising sea levels in the Maldives: A study into aquatic architecture
Frontiers of Architectural Research, 2020 Climate change and rising sea levels present immediate threats to humanity. However, the global catastrophe fails to generate sufficient action. Subject to total submergence within 80 years, this study undertakes an iterative design process seeking ...
Ahdha Moosa, Khoa Do, Emil Jonescu
doaj +1 more source
The cyber security learning and research environment [PDF]
, 2012 This report outlines the design and configuration of the Cyber Security Learning and Research Environment (CLARE). It explains how such a system can be implemented with minimal hardware either on a single machine or across multiple machines.
Bhardwaj, Julian
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cultural Memories for Better Place Experience: The Case of Orabi Square in Alexandria, Egypt
Urban Science, 2020 Globalization is associated with significant transformations in city forms and cultural and social performances. Governments and cultural heritage organisations increasingly appreciate the importance of preserving diverse physical cultural heritage ...
Fatmaelzahraa Hussein +2 more
doaj +1 more source