Results 81 to 90 of about 1,700,007 (268)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Material Metabolism: Reducing Risk through Flexible Formwork Substitution

Buildings
For this special issue, sustainability and safety are discussed through the tropes of both material and work process substitution. As an architecture and industrial design team, we examine the potential of William McDonough’s and Michael Braungart’s ...
Mike Louw, Sally Farrah, Max Maxwell, Sam Tomkins   +3 more
doaj   +1 more source

Application of Cognitive System Model and Gestalt Psychology in Residential Healthy Environment Design. [PDF]

Comput Intell Neurosci, 2022
Yang J, Yuan C.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Home environment design theories and models related to the occupational performance, participation and well-being of people with intellectual disabilities: A scoping review. [PDF]

Br J Occup Ther, 2023
Yong ASL, Haines D, Henry Joseph L.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Application of machine learning-based AI in defect monitoring of earth retaining structures and tunnels of transport systems: A review

Transportation Engineering
The transport system in a modern city is a complex and challenging web of roads, railways, metros, and pedestrian networks. The networks consist of various components, including transport tunnels and earth-retaining structures (ERS).
Md Zahidul Islam, Chin Jian Leo, Ju Jia Zou, Eileen An, Samanthika Liyanapathirana, Pan Hu, Bo Xiao, Stanley Yuen   +7 more
doaj   +1 more source

Co-designing a pedagogical framework and principles for a hybrid STEM learning environment design. [PDF]

Educ Technol Res Dev, 2022
Mäkelä T, Fenyvesi K, Kankaanranta M, Pnevmatikos D, Christodoulou P.   +4 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Classification of road transport earth retaining structures based on improved ConvNeXt V2

Transportation Engineering
An earth-retaining structure (ERS) is a type of wall widely used to support and protect soil, rock, or other earth materials in many parts of transport infrastructure. ERSs are constructed to create grade separation, particularly at inclined locations or
Md Zahidul Islam, Chin Jian Leo, Ju Jia Zou, Eileen An, Samanthika Liyanapathirana, Pan Hu, Bo Xiao, Stanley Yuen   +7 more
doaj   +1 more source