Results 121 to 130 of about 8,702,913 (262)
What is the Department of Environmental Protection?
, 2008 Title from disc label.; "March 2008"--Container.; Harvested from the web on 2/19/09Describes how the employees of the Connecticut Department of Environmental Protection work to fulfill its mission of conserving, protecting, and improving the state's ...
Connecticut. Dept. of Environmental Protection.
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Application Study on Internet of Things in Environment Protection Field
, 2011 The conception of internet of things (IoT) and current situation are introduced and the disadvantages of traditional environment on-line monitor systems are discussed.
Li SX(李世兴) +3 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Environment Protection Agency (Northern Territory)
, 2010 In February 2011, the EPA provided advice to the Minister and the community on the effectiveness of the Department of Resources? response and coordination of the response in relation to an incident at the Rio Tinto mine site at Gove which resulted in 75 ...
Environment Protection Agency (Northern Territory)
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, 2001 This report is an update of the 1998 report. It describes mercury and its effect on the environment. The report includes general information about the health effects and risks of exposure to mercury.
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Demand Side of Social Protection [PDF]
In fragile states, social protection programmes are often a kaleidoscope of projects financed and implemented by a variety of donors, government agencies and NGOs.
DiCaprio, Alisa
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