Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Built Environment and Physical Activity: What Is the Relationship? [PDF]
, 2007 Synthesizes research on how the built environment -- recreational resources, land use mix and connectivity, presence of sidewalks and streetlights, and community environment -- affects residents' physical activity and health across ...
Claudia H. Williams
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Review on Eco-Environment Research in the Yellow River Basin: A Bibliometric Perspective. [PDF]
Int J Environ Res Public Health, 2022 Liu L +6 more
europepmc +1 more source
Effects of digestate on the environment and on plant production - results of a research project [PDF]
, 2008 Composts and digestates can influence soil fertility and plant health. These influences can be positive or negative, depending of the quality of the composts. A currently important question is to know, if digestates differ from composts in these aspects.
Baier, Urs +4 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Health students’ expectations of the ideal educational environment: a qualitative research
Journal of Advances in Medical Education and Professionalism, 2014 Introduction: Educational environment is an important determinant of students’ behavior and its elements are associated with academic achievement and course satisfaction.
TEAMUR AGHAMOLAEI +4 more
doaj
Crowdsourced Data for Physical Activity-Built Environment Research: Applying Strava Data in Chengdu, China. [PDF]
Front Public Health, 2022 Yang L, Yu B, Liang P, Tang X, Li J.
europepmc +1 more source
Effects of compost and digestate on environment and plant production – results of two research projects [PDF]
, 2008 A yearly amount of 9.3x106t compost and digestate derived from separately collected organic waste is produced in the 25 European Union member states. The improvement of soil properties is a major benefit of compost application.
Berner, Alfred +4 more
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source