Results 71 to 80 of about 8,158,113 (255)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Data mining as a tool for environmental scientists [PDF]

, 2006
Over recent years a huge library of data mining algorithms has been developed to tackle a variety of problems in fields such as medical imaging and network traffic analysis.
Athanasiadis, Ioannis, Letcher, Rebecca, Sànchez-Marrè, Miquel, Spate, Jessica, Frank, Eibe, Comas, Joaquim, Gibert, Karina   +6 more
core  

Comparison of Nitroaromatic Compounds Metabolites Types by Sequencing Performance of Anaerobic-Aerobic and Aerobic-Anaerobic Processes

Journal of Environmental Health and Sustainable Development, 2022
Introduction: Xenobiotic contamination is a global concern. Nitroaromatic compounds enter the environment through ammunition, ordnance disposal, burning the outdoors, and leakage of ammunition.
Fahimeh Teimouri, Mohammad Mehdi Amin, Mohsen Sadani, Bijan Bina, Hossein Khanahmad   +4 more
doaj  

Socioeconomic, environmental, and geographic factors and US lung cancer mortality, 1999–2009

Family Medicine and Community Health, 2017
Background: The American Cancer Society estimates that about 25% of all US cancer deaths will be due to lung cancer – more than from cancers of the colon, breast, and prostate combined.
Maria C. Mejia de Grubb, Barbara Kilbourne, Katy Kilbourne, Michael Langston, Lisa Gittner, Roger J. Zoorob, Robert Levine   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Metodología para la localización de un parque de tratamiento y disposición final de residuos sólidos de tipo regional desde una perspectiva multidimensional Methodology for the location of a treatment and solid waste disposal regional park, from a multidimensional perspective

Revista Ingenierías Universidad de Medellín, 2010
El manejo y disposición final de los residuos sólidos en el oriente antioqueño siempre ha sido una preocupación desde CORNARE y los entes territoriales.El artículo presenta los hallazgos de una investigación realizado por el grupo proyecto Ciudad de la ...
Diana Elizabeth Valencia Londoño, Carolina Arias Muñoz, Enrique Vanegas Ospino   +2 more
doaj  

Environmental Information in Financial Statements - “New” Comprehensive Income? [PDF]

Journal of Competitiveness, 2009
The view at an enterprise is changing in connection with the adoption of the concept of sustainable development. An enterprise begins to be perceived as a unity of economic, social, and environmental dimensions.
Dvořáková Dana
doaj  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source