Results 71 to 80 of about 749,364 (313)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Outstanding Master's Thesis Award, Optimal Design of Voluntary "Green" Payment Programs to Limit Nitrate Contamination under Price and Yield Risk, by Jeffrey Peterson; Master's Thesis Award of Merit, Valuing the Benefits of Protecting Groundwater from ...
Anonymous
core +1 more source
Montpelier Community Nursery [PDF]
, 2012 Montpelier Community Nursery is a small building in Kentish Town, London designed for Camden Community Nurseries. The project has wide reach as a model for participatory design processes in dense urban neighbourhoods.
Boulanger, A., Boulanger, A.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Privatization of infrastructure ventures in sectors such as energy, telecommunication, transport, and water has become popular over the last decade. Often- for good or bad reasons - private firms are given monopoly franchises under some type of long-term
Klein, Michael
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A new approach to understanding fluid mixing in process-study models of stratified fluids [PDF]
Nonlinear Processes in GeophysicsWhile well-established energy-based methods of quantifying diapycnal mixing in process-study numerical models are often used to provide information about when mixing occurs, and how much mixing has occurred, describing how and where this mixing has taken
S. G. Hartharn-Evans +4 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Expert Teaching Professors: Sharing Their Expertise
International Journal for the Scholarship of Teaching and Learning, 2009 The purpose of this study was to examine the processes for sharing teaching expertise used by award winning professors. The central research question of this study was: How do expert teaching professors share their expertise with mentees?
Han Shim, Gene Roth
doaj +1 more source