Results 81 to 90 of about 173,357 (309)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Randerson Receives 2017 Piers J. Sellers Global Environmental Change Mid-Career Award

open access: yes, 2017
James Randerson is the inaugural honoree of the Piers J. Sellers Global Environmental Change Mid-Career Award of the American Geophysical Union's Global Environmental Change focus group.
null null
core   +1 more source

Farhana Environmental Scientist receives Royal Education Award Pingat Jaya Cemerlang [PDF]

open access: yes, 2022
KUANTAN, 6 August 2022 - Farhana Munirah Zainuri, the daughter of Zainuri Mohd Shafar, 51, and Zainatunakmar Abdul Manap, 49, is the eldest of three siblings who received the dean’s list certificate every semester and completed her degree in Bachelor of ...
Nur Hartini, Mohd Hatta   +1 more
core  

240 An environmental scan of translational science storytelling in a Clinical Translational Science Award Hub

open access: yesJournal of Clinical and Translational Science
Objectives/Goals: This study illuminates the efforts of a Clinical and Translational Science Award (CTSA) Hub to share stories of its aspirations, challenges, successes, opportunities, and impact when pursuing its complex goals, and how storytelling ...
Boris Volkov   +1 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Fowler receives state bar environmental award

open access: yes, 2016
Congratulations to Adjunct Professor Laurie A. Fowler for receiving the State Bar of Georgia Environmental Law Section Award for 2016. This honor is presented annually to an individual who is experienced and highly skilled in the area of environmental ...
Office of Communications and Public Relations
core  

Ljubljana as a ‘Green’ and Sustainable city–Comparing and Contrasting Various Practices [PDF]

open access: yesIzzivi Prihodnosti, 2017
Purpose and Originality: ‘Greenness’ and sustainability are moving from an abstract concept toward a measurable state, using the triple bottom line approach considering environmental, social, and economic dimensions.
Mihaela Rudar Neral
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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