Results 91 to 100 of about 1,279,052 (360)
FEBS Letters, EarlyView.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
, 2023 This Annual Report covers from 1 January to 31 December ...
core
Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
FEBS Letters, EarlyView.The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine +3 more
wiley +1 more source
Insufficiencies of the 20-TH Century Theories and their Negative Environmental Implications [PDF]
arXiv, 2006 Following a courageous denunciation by Barton Richter in {\it Physics Today,} November 2006, of contemporary particle physics as being "theological speculations," we present insufficiencies of special relativity, quantum mechanics, superconductivity, chemistry, standard model, gravitation and astrophysics for conditions beyond those of their original ...
arxiv
Design and Application of Variable Temperature Environmental Capsule for Scanning Electron Microscopy in Gases and Liquids at Ambient Conditions [PDF]
, 2015 Scanning electron microscopy (SEM) of nanoscale objects in their native conditions and at different temperatures are of critical importance in revealing details of their interactions with ambient environments. Currently available environmental capsules are equipped with thin electron transparent membranes and allow imaging the samples at atmospheric ...
arxiv +1 more source
, 2022 This Annual Report covers from 1 January to 31 December ...
core
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
CO line ratios in molecular clouds: the impact of environment [PDF]
, 2017 Line emission is strongly dependent on the local environmental conditions in which the emitting tracers reside. In this work, we focus on modelling the CO emission from simulated giant molecular clouds (GMCs), and study the variations in the resulting line ratios arising from the emission from the $J=1-0$, $J=2-1$ and $J=3-2$ transitions.
arxiv +1 more source
, 2023 This Annual Report covers from 1 January to 31 December ...
core