Results 101 to 110 of about 1,418,768 (341)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Exploiting fourth-generation synchrotron radiation for enzyme and photoreceptor characterization

IUCrJ
The upgrade of the European Synchrotron Radiation Facility (ESRF) in Grenoble, France to an Extremely Brilliant Source (EBS) is expected to enable time-resolved synchrotron serial crystallography (SSX) experiments with sub-millisecond time resolution ...
Tek Narsingh Malla, Srinivasan Muniyappan, David Menendez, Favour Ogukwe, Aleksandar N. Dale, Joseph D. Clayton, Dominique D. Weatherall, Prabin Karki, Shishir Dangi, Victoria Mandella, A. Andrew Pacheco, Emina A. Stojković, Samuel L. Rose, Julien Orlans, Shibom Basu, Daniele de Sanctis, Marius Schmidt   +16 more
doaj   +1 more source

Characterization of arsenic-rich waste slurries generated during gallium arsenide wafer lapping and polishing [PDF]

, 2009
The toxicology of gallium arsenide is well established; it is classified by the state of California as a known carcinogen. Consequently, environmental aspects of GaAs wafer manufacture are coming under greater scrutiny, with the cost of waste disposal ...
Keenan, H.E., Torrance, K.
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Student viewpoints on the importance and consequences of toxic object management and end of life disposal

Chemistry Teacher International
Over the past few years, batteries have become increasingly more common in electronic devices as part of people’s daily lives. Concerns for the environment have grown due to the improper disposal of these materials which is increasing.
dos Santos Karen Ouverney, Medeiros Machado Murilo, Elias de Almeida Morelli Ruth   +2 more
doaj   +1 more source

Interdisciplinary materials research including fundamental physics and chemistry of materials, environmental effects and related problems Semiannual progress report, Mar. 1 - Aug. 31, 1966 [PDF]

Interdisciplinary materials research including fundamental physics and chemistry of materials, environmental effects and related ...
Sternstein, S. S.
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Science AMA Series: Ask the Society of Environmental Toxicology and Chemistry (SETAC) anything about Pharmaceuticals in the environment! [PDF]

, 2017
SETAC North America, r Science
openalex   +1 more source

Silicon carbide equipments for process intensification of silicon reactions. [PDF]

, 2009
Bluestar Silicones, one of the worldwide leaders in silicones chemistry, proposes a R&D project, aiming to design new equipment for the transposition of batch to continuous processes. The safety and environmental issues linked to this type of chemicals,
Elgue, Sébastien, Ferrato, Marc, Gourdon, Christophe, Jolivet, Claudy, Meille, V., Ramdani, Kamel   +5 more
core