Results 51 to 60 of about 4,691,044 (326)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

open access: yesFEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito   +6 more
wiley   +1 more source

Convolutional neural network prediction of molecular properties for aerosol chemistry and health effects

open access: yesNatural Sciences, 2022
Quinones are chemical compounds commonly found in air particulate matter (PM). Their redox activity can generate reactive oxygen species (ROS) and contribute to the oxidative potential (OP) of PM leading to adverse health effects of aerosols.
Matteo Krüger   +7 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Occurrence and probabilistic risk assessment of PAHs in water and sediment samples of the Diep River, South Africa

open access: yesHeliyon, 2020
This study investigated the levels of polycyclic aromatic hydrocarbons (PAHs) in water and sediment samples of the Diep River freshwater system of Western Cape Province, South Africa.
Adetunji A. Awe   +5 more
doaj  

Challenges for chemical sciences in the 21st century [PDF]

open access: yesHemijska Industrija, 2004
Chemistry and chemical engineering have changed very significantly in the last half century. From classical sciences they have broadened their scope into biology, medicine, physics, material science, nanotechnology, computation and advanced methods of ...
Čeković Živorad
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Environmental toxicology and chemistry (1 November 2017–31 October 2018)

open access: yesEnvironmental Toxicology and Chemistry, 2019
Laboratory testing of sediments frequently involves manipulation by amendment with contaminants and homogenization, which changes the physicochemical structure of sediments.
S. Nedrich   +6 more
semanticscholar   +1 more source

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