Results 61 to 70 of about 1,394,705 (344)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Cold Plasma-Induced Changes in Polyethylene Particles and Their Binding Affinity to Selected Pharmaceuticals

open access: yesMolecules
Environmental contamination with microplastics and trace pharmaceuticals is an increasing ecological and health concern. This study aimed to investigate the effects of low-temperature cold plasma on polyethylene (PE) microplastic particles and to assess ...
Aleksandra Wypart-Pawul   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Direct air capture of CO2 – topological analysis of the experimental electron density (QTAIM) of the highly insoluble carbonate salt of a 2,6-pyridine-bis(iminoguanidine), (PyBIGH2)(CO3)(H2O)4

open access: yesIUCrJ, 2019
Chemical bonding and all intermolecular interactions in the highly insoluble carbonate salt of a 2,6-pyridine-bis(iminoguanidine), (PyBIGH2)(CO3)(H2O)4, recently employed in the direct air capture of CO2 via crystallization, have been analyzed within the
Christopher G. Gianopoulos   +6 more
doaj   +1 more source

ADME/Tox WEB in silico predictions of longer chain perfluoroalkyl carboxylic acid pKa values are more accurate than other computational methods [PDF]

open access: yes, 2009
Perfluoroalkyl carboxylates are contaminants whose environmental fate and toxicological effects are of broad interest within the academic, industrial, and governmental science and regulatory communities.
Kaya Forest, Sierra Rayne
core   +1 more source

Why emerging leaders should focus on being good postdoctoral supervisors

open access: yesFEBS Letters, EarlyView.
Swamped with work and suddenly a new student is waiting at your doorstep for supervision? Great—this is your chance! In this article, we share tips on how postdocs can strengthen their leadership skills while supervising students. This image has been created using DALL·E. Many postdocs work as leaders later in their career.
Hannah Rostalski   +5 more
wiley   +1 more source

Team-Based Project Design for Environmental Chemistry and Entrepreneurship Learning

open access: yesInternational Journal of Research in STEM Education
The aims of this study are to develop a learning design an integrated learning Environmental Chemistry-Entrepreneurial Education (EC-EE) and to investigate its impact on students’ motivation in learning Environmental Chemistry. The development procedure
Rayandra Asyhar   +2 more
doaj   +1 more source

Quantum Control Landscapes

open access: yes, 2007
Numerous lines of experimental, numerical and analytical evidence indicate that it is surprisingly easy to locate optimal controls steering quantum dynamical systems to desired objectives.
Agrachev AA   +5 more
core   +1 more source

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