Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
COVID-19 led to a decline in climate and environmental concern: evidence from UK panel data. [PDF]
Clim Change, 2022 Beiser-McGrath LF.
europepmc +1 more source
Policies Improving Environment in North America, But New Challenges Such As Climate Change Need Attention [PDF]
, 2016 Environmental conditions in North America have improved due to policies, institutions, data collection and assessment, and regulatory frameworks. Air quality, in particular, continues to improve in response to concerted policy action and favorable trends
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Influence of multi-dimensional environmental knowledge on residents' waste sorting intention: Moderating effect of environmental concern. [PDF]
Front Psychol, 2022 He Z, Liu Y, Liu X, Wang F, Zhu H.
europepmc +1 more source
Report of the infrared, ultraviolet and space plasma panels [PDF]
The status of the payload bay and the needs of infrared, ultraviolet and space plasma experiments were discussed. Those measurements important in each area were reviewed.
Lehmann, J. +2 more
core +1 more source
Law, environmental policy and Kantian philosophy [PDF]
, 2012 Are Kantian philosophy and its principle of respect for persons inadequate to the protection of environmental values? This paper answers this question by elucidating how Kantian ethics can take environmental values seriously.
de Paula Oliveira, Maria Lucia
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Drought: a global environmental concern
The Lancet Planetary Health, 2017 Jay D Kravitz
doaj +1 more source