Results 191 to 200 of about 11,405,425 (350)

The Financial Crisis Inquiry Report: Final Report of the National Commission on the Causes of the Financial and Economic Crisis in the United States

, 2011
Final report of the Financial Crisis Inquiry Commission, created to “examine the causes of the current financial and economic crisis in the United States.” This report outlines the findings of the Commission, including collected information broken down ...
United States. Financial Crisis Inquiry Commission.
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Mercury Contamination and Co-exposures in the Amazon Basin: At the Center of the Planetary Environmental Crisis. [PDF]

Ann Glob Health
Lucchini RG, Basta PC, Crespo-Lopez ME, Gastañaga MDC, O'Callaghan-Gordo C, Olivero-Verbel J, Vega C, Moncada Barbosa SM, Espinal C, Felty Q, Deoraj A.   +10 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Environmental Crisis and the Emergence of the Oropouche: A Potential Public Health Problem. [PDF]

Rev Soc Bras Med Trop
Barreto MDS, Santos RS, Santana LADM, Gopalsamy RG, Hariharan G, Brasileiro BF, Gurgel RQ, Correia D, Trento CL, Borges LP.   +9 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Climate and environmental crisis: effects on ear and hearing health in Australia and for Aboriginal and Torres Strait Islander peoples. [PDF]

Med J Aust
Tongs Wiradjuri GM, Ludbrook I, Martin JH, Eisenberg R, Kong Worimi KM.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Microplastic Pollution: A Global Environmental Crisis Impacting Marine Life, Human Health, and Potential Innovative Sustainable Solutions. [PDF]

Int J Environ Res Public Health
Karak P, Parveen A, Modak A, Adhikari A, Chakrabortty S.   +4 more
europepmc   +1 more source