Results 101 to 110 of about 1,526,678 (287)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Environmental Perceptions and Behavioral Change of Hillside Farmers: The Case of Haiti [PDF]
Land degradation is one of the most serious problems facing resource-poor tropical hillside farmers. Studies examining determinants of farmers’ decisions to invest in land improvement technologies have focused on economic and financial factors ...
Bayard, Budry, Jolly, Curtis M.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Environmental regulation in Indonesia [PDF]
, 1994 Since the early 1980s environmental regulation has received high priority in Indonesian policy making. Given Indonesia's dependence upon foreign donors for its economic program, external pressures inevitably played a significant role in stimulating this ...
Elston, K., Warren, C.
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The Influence of short-term land use change on soil evolution in the centre-south coastal areas of Sardinia [PDF]
, 2008 The land use change in short-term (time and space) in the Mediterranean context can be induced by phenomena like destruction of the autochthonous plant species, land abandonment, overgrazing, fire, urbanization (above all for touristic purpose), etc ...
Buondonno, Andrea +3 more
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Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
LINKING LAND QUALITY, AGRICULTURAL PRODUCTIVITY, AND FOOD SECURITY [PDF]
Land quality and land degradation affect agricultural productivity, but quantifying these relationships has been difficult. Data are limited, and impacts are sensitive to the choices that farmers make.
Wiebe, Keith D.
core +1 more source
A global environmental right [PDF]
, 2013 The development of an international substantive environmental right on a global level has long been a contested issue. To a limited extent environmental rights have developed in a fragmented way through different legal regimes.
Turner, Stephen J.
core