Results 101 to 110 of about 2,730,918 (321)

On the Presence of Green and Sustainable Software Engineering in Higher Education Curricula

, 2017
Nowadays, software is pervasive in our everyday lives. Its sustainability and environmental impact have become major factors to be considered in the development of software systems. Millennials-the newer generation of university students-are particularly
Fucci, Davide, Lutovac, Sonja, Procaccianti, Giuseppe, Scanniello, Giuseppe, Torre, Damiano   +4 more
core   +1 more source

100 years of microbial electricity production : three concepts for the future [PDF]

, 2012
Bioelectrochemical systems (BES) have been explored according to three main concepts: to produce energy from organic substrates, to generate products and to provide specific environmental services.
Arends, Jan, Verstraete, Willy
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Experimental evidences of bio-chemo-mechanical processes in contaminated sediments [PDF]

E3S Web of Conferences
The research shows the results of a micro to macro testing programme carried out on contaminated marine sediments from a natural deposit to assess the effects of bio-chemo-mechanical coupled processes which may act in complex natural environments and ...
Sollecito Francesca, Plötze Michael, Puzrin Alexander M., Vitone Claudia, Cotecchia Federica   +4 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Comparison of noise indicators in an urban context [PDF]

, 2016
Inter-Noise 2016, 45th International Congress and Exposition of Noise Control Engineering, HAMBOURG, ALLEMAGNE, 21-/08/2016 - 24/08/2016Noise is a major environmental issue, which gave birth in the last decades to the development of many engineering ...
Aumond, Pierre, Botteldooren, Dick, Can, Arnaud, De Coensel, Bert, Lavandier, Catherine, Michel, Sven, Ribeiro, Carlos   +6 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Allometric equation of Paraserianthes falcataria (L.) and Anthocephalus cadamba Miq. for estimating carbon stocks

Jurnal Presipitasi
Coal mining can increase land degradation and deforestation, so efforts are needed to ensure land use in post-mining areas. Therefore, mining companies must carry out land reclamation to restore the important function of forests by planting sengon laut ...
Kinanto Prabu Werdana, Erri Noviar Megantara, Susanti Withaningsih, Yudha Hadiyanto Eka Saputra   +3 more
doaj   +1 more source