Results 131 to 140 of about 8,455,634 (356)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Services Trade Negotiations in the Doha Round : Opportunities and Risks for Pakistan [PDF]

open access: yes
This paper seeks to examine how locking-in of Pakistans unilateral liberalization at the WTO/GATS and further liberalization of services trade would affect Pakistans competitiveness.
Abid A. Burki, S.M. Turab Hussain
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Comparison of noise indicators in an urban context [PDF]

open access: yes, 2016
Inter-Noise 2016, 45th International Congress and Exposition of Noise Control Engineering, HAMBOURG, ALLEMAGNE, 21-/08/2016 - 24/08/2016Noise is a major environmental issue, which gave birth in the last decades to the development of many engineering ...
Aumond, Pierre   +6 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Cadmium (Cd) tolerance evaluation of three strains of microalgae of the genus Ankistrodesmus, Chlorella and Scenedesmus

open access: yesRevista Facultad de Ingeniería Universidad de Antioquia, 2019
In order to assess tolerance to cadmium (Cd) for three Colombian native strains of microalgae belonging to the genus Ankistrodesmus, Chlorella and Scenedesmus the growth kinetics, the concentration of pigments, the total dry weight in media contaminated
D. Duque, C. Montoya, L. R. Botero
doaj  

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