Results 61 to 70 of about 782,235 (252)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Analyzing MSW Landfill Failures: Stability and Reliability Evaluations from Five International Case Studies

Geotechnics
This study investigates five cases of municipal solid waste (MSW) landfill slope failures in the USA, China, Sri Lanka, and Greece, with the aim of assessing the safety margins and reliability of these slopes.
Filip Dodigovic, Kreso Ivandic, Anja Bek, Jasmin Jug   +3 more
doaj   +1 more source

Impact of land use on soils microbial activity

Journal of Water and Land Development, 2017
The article considered the influence the various types of land use on microbial activity of soils and thus using this parameter as a universal test of soil quality. Samples for soil respiration studies were taken from agricultural areas, meadows, forests
Urbański Krzysztof, Jakubiak Mateusz
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Detailed Review on Sustainable Engineering Methods Integrated with Waste Management Practices [PDF]

E3S Web of Conferences
Environmental engineering is a broad field that considers the complex interactions between natural issues and human action to make long-term arrangements and provide solutions.
Bandhu Din, Umashankari E., V Revathi, Dutt Amit, Kumar Pramod, Ali Abd Ulabbas Abedi Tamam   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Experimental evidences of bio-chemo-mechanical processes in contaminated sediments [PDF]

E3S Web of Conferences
The research shows the results of a micro to macro testing programme carried out on contaminated marine sediments from a natural deposit to assess the effects of bio-chemo-mechanical coupled processes which may act in complex natural environments and ...
Sollecito Francesca, Plötze Michael, Puzrin Alexander M., Vitone Claudia, Cotecchia Federica   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source