Results 101 to 110 of about 307,568 (302)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Estratégias ambientais como alternativas para a prevenção de sintomas de ansiedade e depressão em um modelo experimental da doença de Parkinson em ratos [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2011A doença de Parkinson (DP) é uma doença multifatorial que se caracteriza pela degeneração ...
Savoldi, Robson
core
Enrichment effects on growth, health, and reproduction in a single clone of the asexual Amazon molly, Poecilia formosa [PDF]
PeerJThis study examines the impact of two types of environmental enrichment on the growth of the Amazon molly (Poecilia formosa), a clonal fish species. We investigated the effects of two welfare-related enrichment factors: physical enrichment (presence of a
Debbie Cunningham +4 more
doaj +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Environmental enrichment for big cats
, 2002 This project addresses environmental enrichment for the big cats in the Southwick Zoo. Environmental enrichment is giving the animal back as much control over its life as captivity will allow, promoting the psychological well being of captive animals by ...
Varhegyi, Kira P., Dewilde, Abiche Helen
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Impact of environmental enrichment
This study aimed to investigate the effect of implementing environmental enrichment strategies on the hematological, biochemical, and behavioral indicators of small ruminants kept in confinement, also aiming to assess the effectiveness of these ...
Costa, B (via Mendeley Data)
core +1 more source
Environmental enrichment for zoo-housed Icelandic reindeer (Rangifer tarandus)
, 2021 Environmental enrichment is commonly used to improve the welfare of captive animals by offering options to increase behavioural diversity and normal behaviour patterns. The aim of this study was to assess if environmental enrichment has a positive effect
Kakol, Katarzyna
core
Neurobiology of Disease, 2016 Introduction: The absence epilepsies are presumed to be caused by genetic factors, but the influence of environmental exposures on epilepsy development and severity, and whether this influence is transmitted to subsequent generations, is not well known ...
Gabi Dezsi +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source