Results 111 to 120 of about 6,076,005 (293)

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Developing appropriate environmental enrichment strategies for broiler breeders

Scientific Reports
There is a recognised need for environmental enrichment strategies to be developed for broiler parent stock. We evaluated the use and tested preferences for three forms of enrichment in commercial broiler breeder housing: (1) perches (platform perches ...
Mary Baxter, Niamh E. O’Connell
doaj   +1 more source

Restricted Daily Exposure of Environmental Enrichment: Bridging the Practical Gap from Animal Studies to Human Application [PDF]

Daily restricted environmental enrichment (REE) refers to limited, structured periods of enrichment aimed at improving both physical and cognitive well-being in animals and humans.
Aswir Abd Rashed, Nasarudin, Siti Nur Atiqah Zulaikah, Ramasamy, Rajesh, Rajesh Ramasamy, Abdul Mutalib, Maisarah, Maisarah Abdul Mutalib, Siti Nur Atiqah Zulaikah Nasarudin, Nik Ramli, Nik Nasihah, Abd Rashed, Aswir, Kamarul Sahrin, Nurin Amalia, Mohamad Alwi, Muhammad Najib, Nik Nasihah Nik Ramli, Muhammad Najib Mohamad Alwi, Hashim, Mohamad Hisham, Mohamad Hisham Hashim, Nurin Amalia Kamarul Sahrin   +15 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Environmental enrichment reverses prenatal ethanol exposure-induced attention-deficits in rats

Frontiers in Psychiatry
IntroductionThere is a high prevalence of fetal alcohol spectrum disorders (FASD) in the US and the world, which is caused by prenatal ethanol exposure (PE).
Ruixiang Wang, Connor D. Martin, Anna L. Lei, Kathryn A. Hausknecht, Jerry B. Richards, Samir Haj-Dahmane, Roh-Yu Shen   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Fish density, but not environmental enrichment, affects the size of cerebellum in the brain of juvenile hatchery-reared Atlantic salmon

, 2019
This paper describes a study on the environmentally dependent brain size plasticity in hatchery-reared Atlantic salmon Salmo salar L. Using a factorial experimental design, we tested whether tank fish density, local hatchery standard (150 fish .
Rosengren, Malin, Johnsson, Jörgen I., Näslund, Joacim,, Johnsson, Jörgen I,, Rosengren, Malin,   +4 more
core   +1 more source