Results 91 to 100 of about 5,198,168 (326)

Zaranie, rozwój oraz perspektywy etyki środowiskowej – wybrane zagadnienia

open access: yesStudia Ecologiae et Bioethicae, 2014
The article is an attempt at presenting some aspects of the development of environmental ethics, i.e. the situation in which this discipline evolved, which is referred to as the ecological crisis.
Anna Marek-Bieniasz
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

open access: yesFEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang   +9 more
wiley   +1 more source

[From environmental ethics to environmental bioethics: antecedents, trajectories, and perspectives].

open access: yesHistória, Ciências, Saúde: Manguinhos, 2017
The relationship between humans and the environment became an ethical problem in the twentieth century, when accelerated economic and scientific development was accompanied by profound alterations in global ecological systems.
M. L. Fischer   +4 more
semanticscholar   +1 more source

Deep Ecology and End-of-Life Care

open access: yes, 2009
Physicians and nurses caring for terminally ill patients are expected to center their moral concerns almost exclusively on the needs and welfare of the dying patient and the patients family.
Carrick, Paul
core  

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Ethics of Social Consequences and Evolutionary Ontology in Contemporary Environmental Ethics

open access: yesProfil, 2019
The article deals with an analysis, comparison and evaluation of Evolutionary Ontology by Josef Šmajs and Ethics of Social Consequences by Vasil Gluchman.
Martin Pazdera
doaj   +1 more source

Corporate Sustainability Management and Environmental Ethics

open access: yes, 2017
This article reviews four key orientations in environmental ethics that range from an instrumental understanding of sustainability to one that acknowledges the intrinsic value of sustainable behavior (i.e., sustainable resource use, conservation and ...
D. Schuler   +3 more
semanticscholar   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

open access: yesFEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Introduction to environmental responsibility [PDF]

open access: yes, 2009
[Book summary] The Environmental Responsibility Reader is a definitive collection of classic and contemporary environmental works that offers a comprehensive overview of the issues involved in environmental responsibility, steering the reader through ...
Reynolds, Martin
core  

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