Lead Exposure and Prevention Advisory Committee (LEPAC) : 2021 annual report to U.S. Department of Health and Human Services [PDF]
The objective of the Lead Exposure and Prevention Advisory Committee (LEPAC) is to review research and federal programs and services related to lead poisoning and to identify effective services and best practices for addressing and preventing lead ...
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Fourth national report on human exposure to environmental chemicals. Updated tables, March 2021 : volume three: Analysis of Pooled Serum Samples for Select Chemicals, NHANES 2005-2016 [PDF]
The Fourth National Report on Human Exposure to Environmental Chemicals: Updated Tables, March 2021 (the Updated Tables, March 2021) presents nationally representative, cumulative biomonitoring data gathered from 1999\u20132000 through 2015\u20132016. It
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Public-Place Smoking Laws and Exposure to Environmental Tobacco Smoke (ETS) [PDF]
Public-place smoking restrictions are the most important non-price tobacco control measures worldwide, yet surprisingly little is known about their effects on exposure to environmental tobacco smoke (ETS).
Casey Warman +2 more
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Exposure to toxic environmental agents
Fertility and Sterility, 2013 Reducing exposure to toxic environmental agents is a critical area of intervention for obstetricians, gynecologists, and other reproductive health care professionals. Patient exposure to toxic environmental chemicals and other stressors is ubiquitous, and preconception and prenatal exposure to toxic environmental agents can have a profound and lasting ...
openaire +2 more sources
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Lead Exposure and Prevention Advisory Committee (LEPAC) : 2022 annual report to U.S. Department of Health and Human Services [PDF]
The objective of the Lead Exposure and Prevention Advisory Committee (LEPAC) is to review research and federal programs and services related to lead poisoning and to identify effective services and best practices for addressing and preventing lead ...
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source