Results 161 to 170 of about 7,641,268 (406)

Sun exposure drives Antarctic cryptoendolithic community structure and composition [PDF]

open access: yes, 2019
The harsh environmental conditions of the ice-free regions of Continental Antarctica are considered one of the closest Martian analogues on Earth. There, rocks play a pivotal role as substratum for life and endolithism represents a primary habitat for ...
Coleine, Claudia   +4 more
core  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Measurement Error Correction for Spatially Defined Environmental Exposures in Survival Analysis [PDF]

open access: yesarXiv
Environmental exposures are often defined using buffer zones around geocoded home addresses, but these static boundaries can miss dynamic daily activity patterns, leading to biased results. This paper presents a novel measurement error correction method for spatially defined environmental exposures within a survival analysis framework using the Cox ...
arxiv  

Fish Advisories: Useful Or Difficult to Interpret? [PDF]

open access: yes, 1996
The authors note that fish and shellfish offer significant exposure to environmental toxins but find that consumer knowledge and other factors may limit efforts to control risk in urban ...
Burger, Joanna, Gochfeld, Michael
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

A general approach to modeling environmental mixtures with multivariate outcomes [PDF]

open access: yesarXiv
An important goal of environmental health research is to assess the health risks posed by mixtures of multiple environmental exposures. In these mixtures analyses, flexible models like Bayesian kernel machine regression and multiple index models are appealing because they allow for arbitrary non-linear exposure-outcome relationships.
arxiv  

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Environmental burden of disease resulting from long-term nitrogen dioxide exposure in Germany

open access: yesBMC Public Health
Background Exposure to nitrogen dioxide (NO2) is associated with an increased risk of cardiovascular, respiratory, and other diseases and health outcomes.
Paulina Sell   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy