Results 81 to 90 of about 1,488,207 (218)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Biotic and abiotic properties mediating sediment microbial diversity and function in a river–lake continuum

open access: yesFrontiers in Microbiology
A river–lake system plays an important role in water management by providing long-term and frequent water diversions. However, hydrological connectivity in the system can have a profound effect on sediment microbial communities through pH, nutrient ...
Yabing Gu   +9 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Investigating the Diversity and Influencing Factors of the Rhizosphere Bacterial Community Associated with Salicornia europaea L. Populations in Semi-arid Grassland

open access: yesAgriculture
Salicornia europaea L. is a well-known model plant for studying the mechanism of salt tolerance. A substantial decline in the S. europaea population has been observed in the semi-arid steppe of the Mongolian Plateau.
Hai Wang   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

EXPOSURE TO THE PHYSICAL CONDITIONS OF THE HOME ENVIRONMENT WITH PULMONARY TB DISEASE IN KALUMATA VILLAGE

open access: yesJurnal Berkala Epidemiologi
Background: Pulmonary TB is included in the ten highest disease categories yearly in almost all health centers in Ternate City, North Maluku. In certain age groups, pulmonary TB can be a cause of death.
Siti Washliyah, Purnama Sidebang
doaj   +1 more source

Calibration of Low-Cost NO2 Sensors through Environmental Factor Correction. [PDF]

open access: yesToxics, 2021
Miech JA   +6 more
europepmc   +1 more source

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