Results 61 to 70 of about 1,488,207 (218)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

THE INFLUENCE OF ENVIRONMENTAL FACTORS OF AQUATIC MEDIUM ON MORPHOLOGICAL AND PHYSIOLOGICAL INDICATORS OF PIKE-PERCH (SANDER LUCIOPERCA) AND PERCH (PERCA FLUVIATILIS)

Ribogospodarsʹka Nauka Ukraïni, 2013
Purpose. To study morphometric and morpho-physiological characteristics of percids from geographically separated areas and select the integrated indices of these fish, which characterize the ecological status of the individual water bodies.
M. Prichepa
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Environmental Factors Influencing Annual Changes in Bycatch per Unit Effort of Delphinus delphis around Their Main Hotspot in Korean Waters

Journal of Marine Science and Engineering
In this study, the characteristics of temporal changes in bycatch per unit effort (BPUE) as an index of the relative density of the common dolphin around their widest hotspot in the East Sea/Sea of Japan were examined from 2011 to 2021.
Joon-Taek Yoo, Mi Kyung Lee, Huitae Joo
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Behavioral Patterns, Rather Than Environmental Factors, Shape the Energy Balance of Wintering Chinese Mergansers (Mergus squamatus) in Huangshan

Ecology and Evolution
Animal energy intake and expenditure strategies in response to environmental fluctuations have been widely studied. Optimal foraging theory (OFT) is the dominant framework in this field; however, studies addressing the OFT in endangered waterbird species
Chao Yu, Hao Zheng, Yu Luo, Mengxue Guo, Shiqi Wang, Xuanshuo Qi, Qun Li, Zhonghai Lv   +7 more
doaj   +1 more source

Spatial and seasonal variations of chlorophyll a in Zhanjiang Bay, China, and controlling factors

Frontiers in Marine Science
Based on on-site survey data from 26 stations in the surface seawater of Zhanjiang Bay in April (spring), July (summer), September (autumn), and December (winter) of 2017, the spatial distribution characteristics of chlorophyll a (Chl a) and nutrients in
Shuangling Wang, Shuangling Wang, Shuangling Wang, Fengxia Zhou, Fengxia Zhou, Fengxia Zhou, Fajin Chen, Fajin Chen, Fajin Chen, Qingmei Zhu, Qingmei Zhu, Qingmei Zhu, Yafei Meng, Yafei Meng, Yafei Meng   +14 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Research Progress of the Biosynthesis and Regulation of Andrographolide

Guangdong nongye kexue
Andrographolide is the main active ingredient of Andrographis paniculata, which has the functions of clearing heat and detoxifying, antibacterial and anti-inflammatory, protecting liver and improving gallbladder.
Long ZHANG, Yan GU, Jingyu LI, Shiqiang XU, Mingyang SUN, Xuebo HU, Jihua WANG   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source