Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Quantifying flooding regime in floodplain forests to guide river restoration
Elementa: Science of the Anthropocene, 2014 Determining the flooding regime needed to support distinctive floodplain forests is essential for effective river conservation under the ubiquitous human alteration of river flows characteristic of the Anthropocene Era.
Christian O. Marks +2 more
doaj +1 more source
Taxability of Scholarships and Fellowship Grants [PDF]
, 1963 Stockholm, the capital of Sweden, is a big city with almost one million citizens. The city have got almost 4000 streets of different kinds and it is therefore important to see how the city's cleaning of streets is being managed.
Weiss, Paul J., Jr.
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Rapid desktop assessments of environmental flows [PDF]
Environmental flows / Calculators / Computer techniques / Rivers ...
International Water Management Institute (IWMI).
core
Appraisal of the environmental sustainability of milk production systems in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Science in Life Cycle Management at Massey University, Manawatū, New Zealand [PDF]
, 2016 Life Cycle Assessment (LCA) plays an important role in the environmental assessment of agricultural product systems, including dairy farming systems.
Chobtang, Jeerasak
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Modelling the dynamics of turbulent floods [PDF]
, 2002 Consider the dynamics of turbulent flow in rivers, estuaries and floods. Based on the widely used k-epsilon model for turbulence, we use the techniques of centre manifold theory to derive dynamical models for the evolution of the water depth and of ...
Birkhoff Garrett +5 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source