Results 111 to 120 of about 148,517 (308)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Agricultural Policies and Environmental Interaction in OECD Contries [PDF]
Agriculture is heavily subsidized in most of the OECD countries. On the other hand, environmental externalities occur because of protection related pollution.
Cemal Atici
core
Timeseries of wave data extracted from .grb2 files. Timeseries contain a 30-year wave climatology that has been generated with the NOAA WAVEWATCH III® using the Ardhuin et al (2010) physics package, 15 regular lat-lon grids, and the NCEP Climate Forecast
Harm 'Jaap' Nienhuis, Jacob +1 more
core +1 more source
Recent developments in liability for environmental harm
, 2022 Tradicionalno odškodninsko pravo nudi zgolj omejeno varstvo okolju, saj je primarno namenjeno povrnitvi škode, ki nastane posamezniku zaradi posega v pravno varovane dobrine, kot so človekovo življenje, telesna integriteta, zdravje in zasebna lastnina. V
Tanko, Gaja
core
Infrastructures of Harm, Communities of Knowledge and Environmental Justice
Studies in Social Justice, 2023 Ysabel Munoz Martinez, Jerome Nenger
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source