Results 101 to 110 of about 5,342,131 (351)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

MARYLAND\u27S NEXT SMART GROWTH INITIATIVE: THE NEXT STEPS [PDF]

, 2002
This article discusses Maryland\u27s Smart Growth and Neighborhood Conservation Initiative, the nation\u27s first statewide, incentive-based program to reduce the impact of urban sprawl.
Glendening, Parris N.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Environmental Self-Auditing: Setting the Proper Incentives for Discovering and Correcting Environmental Harm [PDF]

, 1998
Since the 1970's, the amount of environmental regulation at all levels of government has increased significantly. Major federal statutes include the Clean Air Act, Federal Water Pollution Act, Resource Conservation and Recovery Act (RCRA), Toxic ...
Sanchirico, Chris William, Talikoff, Alexander Strickland Pfaff   +1 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Environmental Harm Resulting from Israeli Bombing of Gaza: Legal Aspects

Arab Studies Quarterly
Israel’s unprecedented bombardment of the Gaza Strip has caused more than 100,000 casualties and the forced displacement of most of Gaza’s 2.3 million inhabitants, but there is a “silent victim”: the environment, which includes the natural and built ...
Joni Aasi
doaj   +1 more source

Autonomous Interpretation of ‘Civil and Commercial Matters’: Do Public Authorities’ Claims for Clean-up Costs for Pure Environmental Harm Qualify?

Oslo Law Review, 2019
Recovery of public authorities’ costs for pure environmental harm, ie harm that does not entail an economic loss on part of the authorities, is unlikely to be considered a ‘civil matter’ under Rome II – or the Judgments Regulation/Lugano Convention.
Henrik Bull
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Measuring Beliefs Supportive of Environmental Action and Inaction: A Reinterpretation of the Awareness of Consequences Scale [PDF]

The Value-Belief-Norm model assumes that egoistic, social-altruistic and biospheric value orientations causally influence how people cognitively structure beliefs regarding adverse environmental consequences.
Ryan, Anthony M., Spash, Clive L.
core   +1 more source

Seeing environmental violence in deep time: perspectives from contemporary Mongolian literature and music [PDF]

, 2018
What does it mean to do violence in deep time? How is deep time evoked in our understanding of environmental harm? Environmental transformations have figured prominently in the recent history of Mongolia.
Basso, Bender, Billé, Borjigin, Bulag, Bulag, Byambadorj, Cohen, de la Cadena, Delaplace, Dovchin, Empson, Empson, Gell, Gell, High, Humphrey, Humphrey, Ingold, Ingold, Irvine, Jackson, Kaplonski, Kaplonski, Marin, McPhee, Mend-Ooyo, Mend-Ooyo, Mend-Ooyo, Munn, Munn, Murphy, Nixon, Pocock, Robinson, Sneath, Sneath, Sternberg, Suzuki, Tao, Tilley, Wickham-Smith   +41 more
core   +2 more sources