Results 71 to 80 of about 148,517 (308)

Cue reactivity to self-harm cues: the development of a systematic treatment intervention for deliberate self-harm

open access: yes, 2009
There is increasing awareness of the prevalence of deliberate self-harm (DSH) although the phenomenon is still poorly understood. Those who self-harm often have a poor long-term prognosis, yet systematic focused treatment interventions are scarce.
Hepworth, Claire Rachel
core  

The Criminalization of Environmental Harm: Theoretical Perspectives in the European Union

open access: yesProphetic Law Review
Climate change poses a serious threat to the health and well-being of people and the environment and is one of the most pressing issues facing the European Union today.
Krisztina Ficsor
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Self-harm in East London adolescents

open access: yes, 2010
PhDThe prevalence of adolescent self-harm is higher in the community compared with self-harm monitored through service use, as only a minority of young people seek help. There has been limited longitudinal community-based research on adolescent self-harm,
Klineberg, Emily
core  

Green Criminology: Evolution, Typology, and Legal Framework for Environmental Protection

open access: yesIus Poenale
Green criminology (GC) offers a critical lens for understanding the dynamics of environmental harm, moving beyond Classical Criminology (CC Green Criminology (GC) offers a framework for understanding environmental harm, extending beyond Classical ...
Muhamad Pelengkahu
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Of Fish and Fishermen: Shifting Societal Baselines to Reduce Environmental Harm in Fisheries

open access: yesEcology and Society, 2012
If reasonable fishery harvests and environmental harms are specified in new regulations, policies, and laws governing the exploitation of fish for food and livelihoods, then societal baselines can shift to achieve sustainable fisheries and marine ...
Mimi E. Lam
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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