Results 91 to 100 of about 795,117 (293)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Utilización de documentos históricos en la reconstrucción de la vegetación de la Llanura de la Travesía (Argentina) a principios del siglo XIX The use of historical documents to reconstruct the vegetation of the Llanura de la Travesía (Argentina) during early nineteenth century

Revista Chilena de Historia Natural, 2003
La Llanura de la Travesía se extiende en las provincias de Mendoza y San Luis (Argentina) entre el piedemonte de los Andes y las Sierras Pampeanas. El objetivo de este trabajo fue reconstruir las condiciones ambientales de la Llanura de la Travesía a ...
MARÍA DEL ROSARIO PRIETO, PABLO EUGENIO VILLAGRA, NERINA BELÉN LANA, ELENA MARÍA ABRAHAM   +3 more
doaj  

Environmental History

, 2005
No abstract available."Environmental History." with D. Rodriguez. Interdisciplinary Grant, Center for Interdisciplinary and Integrative Studies, CSUCI.
Donald Rodriguez, Rainer F. Buschmann
core  

Can environmental history save the world? [PDF]

, 2008
As a 'genre of history' in Australia environmental history is relatively new, emerging in the 1960s and 70s from encounters between history, geography and the natural sciences in the context of growing environmental concern and activism ...
Goodall, Heather., Gaynor, Andrea, Mullins, Steve, 1952-, Steve Mullins, Dovers, Steve, S Brown (7745285), Andrea Gaynor, Steve Dovers, Stephen Mullins (9821426), Mullins, S, Brown, Sarah, S Dovers (9876776), Sarah Brown, Dovers, S, Frawley, Jodi, Frawley, JE, Heather Goodall, Dovers, Stephen., A Gaynor (9876782), Frawley, Jodi., Goodall, Heather, Mullins, Steven, Brown, Sarah., Karskens, Grace, H Goodall (9876785), Karskens, G, Brown, S, Goodall, H, G Karskens (9876788), Grace Karskens, J Frawley (9876779), Karskens, Grace., Jodi Frawley, Gaynor, Andrea., Gaynor, A   +34 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Environmental assessment of pesticide use in the cerrado region of Brazil [PDF]

Ambiente & Sociedade
The Cerrado in Central Brazil is composed of unique vegetation types with a large source of bioactive compounds. The 1970s and 1980s were marked by the intensive incorporation of these forested areas into pastures and cropland, which increased the ...
Marina Teodoro, Vitor S. Duarte, Mariana R. M. Costa, Ryan Nehring, Sandro D. Silva, Giovanni A. Boggione, Hamilton B. Napolitano   +6 more
doaj   +1 more source

Effect of environmental history on the habitat-forming kelp Macrocystis pyrifera responses to ocean acidification and warming: a physiological and molecular approach. [PDF]

Sci Rep, 2021
Fernández PA, Navarro JM, Camus C, Torres R, Buschmann AH.   +4 more
europepmc   +1 more source

Introduction: Environmental History and the History of Biology [PDF]

Journal of the History of Biology, 2010
Libby, Robin, Jane, Carruthers
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source