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Environmental History Podcast

open access: yes
Environmental History Resources is a fantastic website, maintained by Dr. Jan Oosthoek, an environmental historian based at the University of Newcastle, that explores how "environmental changes, often the result of human actions, have caused ...

core  

Environmental News You Can Use [PDF]

open access: yes, 2005
Monthly newsletter of the Texas Commission on Environmental Quality containing information on environmental topics of interest to the general public and other groups including municipalities, businesses, corporate environmental managers, school teachers,
Texas Commission on Environmental Quality. Small Business and Environmental Assistance Division.
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The problem of the problem of environmental history: A re-reading of the field and its purpose

open access: yes, 2007
This essay argues that environmental history has not engaged as fully with social and political theory as it might, and that once it does, environmental historians will find that their concerns are, potentially, much closer to the mainstream of thought ...
Sörlin, Sverker,   +2 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

"CUANDO EL RÍO SUENA, PIEDRAS TRAE": RELAVES DE COBRE EN LA BAHÍA DE CHAÑARAL, 1938-1990 "IF THE RIVER SOUNDS IT IS BECAUSE IT IS CARRYING ROCKS": COPPER TAILINGS IN THE BAY OF CHAÑARAL, 1938-1990

open access: yesCuadernos de Historia, 2011
Desde la perspectiva de la historia ambiental, en este trabajo se analiza el impacto de la Gran Minería del Cobre en la provincia de Chañaral entre 1938 y 1990.
Angela Vergara
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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