Results 51 to 60 of about 671,747 (252)
Initial limnological observations at five small lakes in southern Pacific Costa Rica
Cuadernos de investigación UNED, 2018 Costa Rica has hundreds of lakes, many of which have never been described or sampled by limnologists. Here we summarize initial observations of five small (0.2–1.7ha) lakes located at low elevation (365–490m) in the cantón of Buenos Aries.
Sally P. Horn +6 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Projets de PaysageThrough an analysis of approximately five hundred letters exchanged between 1662 and 1686 by the people involved in the building of the gardens of Chantilly at the time of Le Nôtre, this article demonstrates the importance of observation in the ...
Serge Briffaud, Emmanuelle Heaulmé
doaj +1 more source
Retracted: Exploration and Analysis of Educational History from the Perspective of Educational Environmental History and Environmental History. [PDF]
J Environ Public Health, 2023 Environmental And Public Health JO.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Extreme Spaces as Encounters: Images, Environments, and Otherness
ArtsSpaces labeled as ‘extreme’ have long fueled the imagination of those who sought to explore, conquer, and represent them. Framed in colonial narratives as terra incognita or finis terrae, these regions generated diverse forms of textual and visual ...
Maria Berbara +2 more
doaj +1 more source