Results 61 to 70 of about 671,747 (252)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Identifying Recruitment Sources Across Trophic Levels in a Large River Food Web
Ecology and EvolutionAssemblages are connected through the movement of physical and biological resources including recruits. Identifying recruitment sources for predators and their prey could help us understand how assemblages use connectivity across multiple trophic levels ...
Shaley A. Valentine +2 more
doaj +1 more source
VertigO, 2016 A series of large hydro-electrical dams was built on the Dordogne River over the course of the twentieth century. Given the historical prevalence of floods in the basin, it is striking to find virtually no mention of flood risk or vulnerability in the ...
Alexis Metzger, Jamie Linton
doaj +1 more source
Speleological and environmental history of Lida Ajer cave, western Sumatra. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2022 Louys J +15 more
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Acta CarsologicaThe findings of environmental history are in the service of ecology and represent an important contribution to the understanding of the sustainable management of land. The aim of this article is to shed light on the relations between the local population
Nikita Peresin Meden
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Fields: The Transformation and Healing of the Whitewater Valley
Open Rivers, 2018 They say hindsight is 20/20. Farmers of the past didn’t have information about environmentally friendly agricultural techniques. The farming techniques used today to reduce erosion and other negative environmental effects were developed as we learned ...
Maria DeLaundreau
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Revista Chilena de Historia Natural, 2003 La Llanura de la Travesía se extiende en las provincias de Mendoza y San Luis (Argentina) entre el piedemonte de los Andes y las Sierras Pampeanas. El objetivo de este trabajo fue reconstruir las condiciones ambientales de la Llanura de la Travesía a ...
MARÍA DEL ROSARIO PRIETO +3 more
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