Results 51 to 60 of about 484,749 (259)

A clean energy Korea by 2035: Transitioning to 80% carbon-free electricity generation

open access: yesCell Reports Sustainability
Summary: South Korea relies on imported fossil fuels for over 60% of its electricity generation, making it vulnerable to energy security risks and fuel price volatility.
Won Young Park   +12 more
doaj   +1 more source

Physically based approaches incorporating evaporation for early warning predictions of rainfall-induced landslides [PDF]

open access: yesNatural Hazards and Earth System Sciences, 2018
In the field of rainfall-induced landslides on sloping covers, models for early warning predictions require an adequate trade-off between two aspects: prediction accuracy and timeliness.
A. Reder, A. Reder, G. Rianna, L. Pagano
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Assessment of Regional Adaptation Strategies in Greece

open access: yesAtmosphere
Despite the institutional establishment of Regional Adaptation Action Plans (RAAPs), no systematic cross-regional assessment has examined their structure and implementation dynamics.
Despoina Charchousi   +4 more
doaj   +1 more source

State-wide California 2020 carbon dioxide budget estimated with OCO-2 and OCO-3 satellite data [PDF]

open access: yesAtmospheric Chemistry and Physics
Satellite observations are instrumental in observing spatiotemporal variability in carbon dioxide (CO2) concentrations, which can be used to derive fluxes of this greenhouse gas. This study leverages NASA's Orbiting Carbon Observatory-2 and -3 (OCO-2 and
M. S. Johnson   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Quantifying projected changes in runoff variability and flow regimes of the Fraser River Basin, British Columbia [PDF]

open access: yesHydrology and Earth System Sciences, 2019
In response to ongoing and future-projected global warming, mid-latitude, nival river basins are expected to transition from a snowmelt-dominated flow regime to a nival–pluvial one with an earlier spring freshet of reduced magnitude. There is, however, a
S. U. Islam   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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