Results 121 to 130 of about 1,493,909 (303)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Lake trophic state indicator shows non-stationary relationships with environmental drivers

Ecological Indicators
Understanding drivers of water quality is critical for anticipating and managing lake ecosystems under global change. While theoretical relationships between drivers (air temperature) and water quality (chlorophyll-a) are well understood, it remains ...
Whitney Woelmer, Rose Gregersen, Deniz Özkundakci   +2 more
doaj   +1 more source

Environmental Indicators and Their Applications (Trends of Activity and Development) [PDF]

, 1994
Environmental problems are complex: the same problem may have several causes and the same stress may cause several problems. An environmental indicator is a number that is meant to indicate the state of development of important aspects of the environment.
Malkina-Pykh, I.G., Pykh, Y.A.
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Scarabaeidae family (Coleoptera) as potential environmental quality bioindicator | Família Scarabaeidae (Coleoptera) como bioindicador de potencial de qualidade ambiental

Revista Geama, 2017
Insects are widely used as biological indicators of environmental quality in environmental monitoring studies, because they have certain aspects that help in the identification of environmental stress. The genus Dichotomius, from the family Scarabaeidae,
Adriana Aparecida Megumi Nishiwaki, Sara Maria Gomes Pinheiro, Luciana de Omena Gusmão, Eduardo Cabral da Silva, André Felipe de Melo Sales Santos, Soraya Giovanetti El-Deir   +5 more
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Penerapan Sikap Kepedulian Lingkungan Dalam Model Sains Teknologi Masyarakat Dalam Konsep Ekologi Dan Pencemaran Lingkungan [PDF]

, 2016
The purpose of the study is to find out the implementation of environmental awareness attitude of senior high school students for ecology and environment pollution concept through the implementation of the society technology science (STS) model.
Herlanti, Y. (Yanti), Rahmawati, R. (Rahmawati), Sugiarti, S. (Sugiarti)   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

ECONOMIC, ECOLOGICAL, AND SOCIAL DIMENSIONS OF INDUSTRIAL ENTERPRISES ENVIRONMENTAL SECURITY AND SUSTAINABILITY ENSURING

Фінансово-кредитна діяльність: проблеми теорії та практики
Industrial enterprise environmental security assessment refers to the assessment and analysis of industrial environmental security measures and vulnerabilities to protect against potential threats and risks to the environment.
Марина Мащенко, Олена Сергієнко, Марина Татар, Олена Кліменко, Лариса Тєшева, Юрій Камельчук   +5 more
doaj   +1 more source