Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
The potential role of Escherichia coli as an indicator of environmental antimicrobial resistance in an urban river in Japan. [PDF]
Matsui K +4 more
europepmc +1 more source
Heterotropic regulation and negative homotropic cooperativity
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Bacterial community shifts in response to arsenic and cadmium contamination in aquatic ecosystems: a microcosm study. [PDF]
Lee H +8 more
europepmc +1 more source
Regression Analysis of the Main Environmental Risk Factors for Mountainous Subtype of Zoonotic VL in China. [PDF]
Li Z +7 more
europepmc +1 more source
Environmental enrichment reduces displacements and reorganises circadian patterns: a putative indicator of positive welfare in dairy calves. [PDF]
Thomas M +3 more
europepmc +1 more source
A multi-criteria framework for assessing the natural resource potential of agricultural landscapes using Harrington's generalized desirability function. [PDF]
Omarov A +5 more
europepmc +1 more source
Long-Term Fluctuations in Cetacean Occurrence Derived From Whale-Watching Platforms Off Southwest Gran Canaria: Evaluating Their Potential as an Ecological Indicator. [PDF]
Herrera I +3 more
europepmc +1 more source
Integrating Water Column and Sediment eDNA Metabarcoding Reveals Seasonal Turnover and Habitat-Specific Differentiation of Fish Communities in a Subtropical Coastal Bay. [PDF]
Xu S, Xiao Y, Li M, Fan J, Chen Z.
europepmc +1 more source

