Results 41 to 50 of about 431,544 (308)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Comprehensive evaluation of the eco-environmental vulnerability in the Yellow River Delta wetland

Ecological Indicators, 2021
The eco-environmental vulnerability is an important indicator of the development in wetland. However, the vulnerability is influenced by various interacting factors.
Hongyang Zhang, Yadong Sun, Wenxin Zhang, Ziyi Song, Zelin Ding, Xianqi Zhang   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

, as a potential indicator of environmental pesticide contamination

, 2015
Neonicotinoids have the potential to enter the diet of pollinators that collect resources from contaminated plants. The species Scaptotrigona aff. depilis (Moure, 1942) can be a useful indicator of the prevalence of these chemicals in the environment ...
Betina Blochtein, Blochtein, B., I'Anson Price, R., Maria Juliana Ferreira Caliman, Robbie I'Anson Price, Elisa Pereira Queiroz, Ferreira Caliman, M.J., de Souza Rosa, A., Imperatriz-Fonseca, V.L., Vera Lucia Imperatriz‐Fonseca, Sílvia Soares Pires, C., Annelise de Souza Rosa, Pereira Queiroz, E., Carmen Sílvia Soares Pires   +13 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Ecological Footprint Policy? Land Use as an Environmental Indicator

, 2014
Summary: This article argues that policies aimed at sustainability need to address the spatial dimensions of environmental problems and their solutions.
van den Bergh, J.C.J.M., Grazi, F.
core   +1 more source

Environmental quality integrated indicator applied to the management of the Jiquiriçá river watershed, BA, Brazil

Revista Ambiente & Água, 2010
In this work social, economic and environmental aspects were studied using the concept of programming by commitment, with the objective of structuring an integrated indicator capable of estimating the degree of the environmental quality of the Jiquiriça ...
Raquel Maria de Oliveira, Neylor Alves Calasans Rego, José Wildes Barbosa dos Santos, Max de Menezes, Jadson Luiz Simões Rocha   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Biomimetic Fe-bearing nanoparticles in hot spring: morphology, origin and potential bioavailable Fe

Frontiers in Earth Science
Iron is a critical redox-active element in geothermal water, and the presence of nanoparticulate Fe is essential in comprehending the intricate cycling of iron and related elements within the natural geothermal ecosystems.
Zhaoying Chen, Rui Liu, Yaqin Wang, Bo Lu, Yuxiang Cui, Lei Zuo, Peng Zhang, Yaqing Wang, Cong Cao   +8 more
doaj   +1 more source