Results 121 to 130 of about 374,565 (262)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Geosalud: relaciones geográficas entre salud y ambiente Geohealth: geographic relations between health and environment

Revista Cubana de Higiene y Epidemiología, 2004
En respuesta a los intereses del PNUMA y la OPS, se hace necesario incorporar el componente salud dentro de las prioridades del proyecto GEO, que hasta el momento solo ha logrado representar el comportamiento de los problemas ambientales a nivel mundial ...
Dianelis Pérez Jiménez, Pedro Más Bermejo, Vicente Prieto Díaz, Miriam Rodríguez González <a name=autor></a>   +3 more
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Monitoring boreal avian populations: how can we estimate trends and trajectories from noisy data?

Avian Conservation and Ecology, 2019
Substantial effort has been dedicated to developing reliable monitoring schemes for North American bird populations, but our ability to monitor bird populations in the boreal forest remains limited because of the sparsity of long-term data sets ...
Christian Roy, Nicole L. Michel, Colleen M. Handel, Steven L. Van Wilgenburg, J. Curtis. Burkhalter, Kirsty E. B. Gurney, David J. Messmer, Karine Princé, Clark S. Rushing, James F. Saracco, Richard Schuster, Adam C. Smith, Paul A. Smith, Péter Sólymos, Lisa A. Venier, Ben Zuckerberg   +15 more
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Investigation on the Influence Mechanisms and Graded Monitoring of CO₂ Leakage on Surface Water Environmental Indicators. [PDF]

ACS Omega
Zhen M, Ke W, Shui H, Wang Z, Nie F.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Contextual factors in the surveillance of non-communicable diseases (NCD) in Germany: political, social and environmental indicators. [PDF]

J Health Monit
Neuperdt L, Tuncer O, Mumm R, Jordan S, Starker A, Manz K, Müters S, Heidemann C.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The use of fish diversity and abundance as environmental indicators in a mining region in Brazilian Amazonia. [PDF]

Sci Rep
de Oliveira CACR, Morais KS, de Oliveira JPS, de Oliveira Marques A, da Silva ABF, da Conceição Palheta D, Bentes B.   +6 more
europepmc   +1 more source