Results 171 to 180 of about 6,972,234 (329)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

INVESTIGATING THE RELATIONSHIP BETWEEN YIELD RISK AND AGRI-ENVIRONMENTAL INDICATORS [PDF]

Crop insurance provides risk reduction benefits yet may increase planted acres in risky areas. This paper investigates the relationship between environmental quality and crop insurance induced changes in cropping pattern.
Clark, Nathan, Fleming, Ronald A., Skees, Jerry R.   +2 more
core   +1 more source

A policy relevant assessment of the environmental impacts of organic farming [PDF]

, 2000
Organic farming has become an important aspect of European agri-environmental policy. Since the implementation of EC Reg. 2078/92, the EU promotes organic farming based explicitly on its positive effects on the environment. The objective of this paper is
Dabbert, S., Häring, A.M., Piorr, A., Stolze, M.   +3 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

EXPERT SYSTEMS FOR ENVIRONMENTAL PROTECTION IN MINING

Rudarsko-geološko-naftni Zbornik, 2012
Expert systems are used in various activities with the main goal of decision-making in intelligent and transparent way. In business decision-making, such systems are directed to pure operational and economical decisions.
Damir Rumenjak
doaj  

SEEA Revision: Accounting for Sustainability? [PDF]

The 1993 United Nations System for integrated Environmental and Economic Accounting (SEEA) aimed at measuring the - environmental - sustainability of economic performance and growth in terms of produced and natural capital maintenance.
Peter Bartelmus
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

An ecological study of the association between environmental indicators and early childhood caries. [PDF]

BMC Res Notes, 2020
Folayan MO, Tantawi ME, Gaffar B, Schroth RJ, Catillo JL, Al-Batayneh OB, Kemoli A, Díaz ACM, Pavlic V, Raswhan M, Group FECCA.   +10 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source